Literature DB >> 34688407

Making Lemonade: Putting the Wisdom of the Genome to Work in Atopic Dermatitis.

Zhaolin Zhang1, James T Elder2.   

Abstract

Getting from a GWAS hit to an actionable gene remains a challenge in complex disease genetics. In a new article of the Journal of Investigative Dermatology, Sobczyk et al. (2021) use a wide variety of genomic data to generate a prioritization algorithm to tackle this problem in atopic dermatitis, calling on the wisdom of the genome to generate promising results.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2021        PMID： 34688407      PMCID： PMC8594458          DOI： 10.1016/j.jid.2021.05.027

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  9 in total

1.  Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity.

Authors:  Xiaotian Zhang; Mira Jeong; Xingfan Huang; Xue Qing Wang; Xinyu Wang; Wanding Zhou; Muhammad S Shamim; Haley Gore; Pamela Himadewi; Yushuai Liu; Ivan D Bochkov; Jaime Reyes; Madison Doty; Yung-Hsin Huang; Haiyoung Jung; Emily Heikamp; Aviva Presser Aiden; Wei Li; Jianzhong Su; Erez Lieberman Aiden; Margaret A Goodell
Journal:  Mol Cell       Date:  2020-05-07       Impact factor: 17.970

2.  Discovery of stimulation-responsive immune enhancers with CRISPR activation.

Authors:  Dimitre R Simeonov; Benjamin G Gowen; Mandy Boontanrart; Theodore L Roth; John D Gagnon; Maxwell R Mumbach; Ansuman T Satpathy; Youjin Lee; Nicolas L Bray; Alice Y Chan; Dmytro S Lituiev; Michelle L Nguyen; Rachel E Gate; Meena Subramaniam; Zhongmei Li; Jonathan M Woo; Therese Mitros; Graham J Ray; Gemma L Curie; Nicki Naddaf; Julia S Chu; Hong Ma; Eric Boyer; Frederic Van Gool; Hailiang Huang; Ruize Liu; Victoria R Tobin; Kathrin Schumann; Mark J Daly; Kyle K Farh; K Mark Ansel; Chun J Ye; William J Greenleaf; Mark S Anderson; Jeffrey A Bluestone; Howard Y Chang; Jacob E Corn; Alexander Marson
Journal:  Nature       Date:  2017-08-30       Impact factor: 49.962

3.  Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

Authors:  Anubha Mahajan; Daniel Taliun; Matthias Thurner; Neil R Robertson; Jason M Torres; N William Rayner; Anthony J Payne; Valgerdur Steinthorsdottir; Robert A Scott; Niels Grarup; James P Cook; Ellen M Schmidt; Matthias Wuttke; Chloé Sarnowski; Reedik Mägi; Jana Nano; Christian Gieger; Stella Trompet; Cécile Lecoeur; Michael H Preuss; Bram Peter Prins; Xiuqing Guo; Lawrence F Bielak; Jennifer E Below; Donald W Bowden; John Campbell Chambers; Young Jin Kim; Maggie C Y Ng; Lauren E Petty; Xueling Sim; Weihua Zhang; Amanda J Bennett; Jette Bork-Jensen; Chad M Brummett; Mickaël Canouil; Kai-Uwe Ec Kardt; Krista Fischer; Sharon L R Kardia; Florian Kronenberg; Kristi Läll; Ching-Ti Liu; Adam E Locke; Jian'an Luan; Ioanna Ntalla; Vibe Nylander; Sebastian Schönherr; Claudia Schurmann; Loïc Yengo; Erwin P Bottinger; Ivan Brandslund; Cramer Christensen; George Dedoussis; Jose C Florez; Ian Ford; Oscar H Franco; Timothy M Frayling; Vilmantas Giedraitis; Sophie Hackinger; Andrew T Hattersley; Christian Herder; M Arfan Ikram; Martin Ingelsson; Marit E Jørgensen; Torben Jørgensen; Jennifer Kriebel; Johanna Kuusisto; Symen Ligthart; Cecilia M Lindgren; Allan Linneberg; Valeriya Lyssenko; Vasiliki Mamakou; Thomas Meitinger; Karen L Mohlke; Andrew D Morris; Girish Nadkarni; James S Pankow; Annette Peters; Naveed Sattar; Alena Stančáková; Konstantin Strauch; Kent D Taylor; Barbara Thorand; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jaakko Tuomilehto; Daniel R Witte; Josée Dupuis; Patricia A Peyser; Eleftheria Zeggini; Ruth J F Loos; Philippe Froguel; Erik Ingelsson; Lars Lind; Leif Groop; Markku Laakso; Francis S Collins; J Wouter Jukema; Colin N A Palmer; Harald Grallert; Andres Metspalu; Abbas Dehghan; Anna Köttgen; Goncalo R Abecasis; James B Meigs; Jerome I Rotter; Jonathan Marchini; Oluf Pedersen; Torben Hansen; Claudia Langenberg; Nicholas J Wareham; Kari Stefansson; Anna L Gloyn; Andrew P Morris; Michael Boehnke; Mark I McCarthy
Journal:  Nat Genet       Date:  2018-10-08       Impact factor: 38.330

4.  Widespread plasticity in CTCF occupancy linked to DNA methylation.

Authors:  Hao Wang; Matthew T Maurano; Hongzhu Qu; Katherine E Varley; Jason Gertz; Florencia Pauli; Kristen Lee; Theresa Canfield; Molly Weaver; Richard Sandstrom; Robert E Thurman; Rajinder Kaul; Richard M Myers; John A Stamatoyannopoulos
Journal:  Genome Res       Date:  2012-09       Impact factor: 9.043

5.  Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Authors:  Kyle Kai-How Farh; Alexander Marson; Jiang Zhu; Markus Kleinewietfeld; William J Housley; Samantha Beik; Noam Shoresh; Holly Whitton; Russell J H Ryan; Alexander A Shishkin; Meital Hatan; Marlene J Carrasco-Alfonso; Dita Mayer; C John Luckey; Nikolaos A Patsopoulos; Philip L De Jager; Vijay K Kuchroo; Charles B Epstein; Mark J Daly; David A Hafler; Bradley E Bernstein
Journal:  Nature       Date:  2014-10-29       Impact factor: 49.962

6.  Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

Authors:  Lavinia Paternoster; Marie Standl; Johannes Waage; Hansjörg Baurecht; Melanie Hotze; David P Strachan; John A Curtin; Klaus Bønnelykke; Chao Tian; Atsushi Takahashi; Jorge Esparza-Gordillo; Alexessander Couto Alves; Jacob P Thyssen; Herman T den Dekker; Manuel A Ferreira; Elisabeth Altmaier; Patrick Ma Sleiman; Feng Li Xiao; Juan R Gonzalez; Ingo Marenholz; Birgit Kalb; Maria Pino Yanes; Cheng-Jian Xu; Lisbeth Carstensen; Maria M Groen-Blokhuis; Cristina Venturini; Craig E Pennell; Sheila J Barton; Albert M Levin; Ivan Curjuric; Mariona Bustamante; Eskil Kreiner-Møller; Gabrielle A Lockett; Jonas Bacelis; Supinda Bunyavanich; Rachel A Myers; Anja Matanovic; Ashish Kumar; Joyce Y Tung; Tomomitsu Hirota; Michiaki Kubo; Wendy L McArdle; A J Henderson; John P Kemp; Jie Zheng; George Davey Smith; Franz Rüschendorf; Anja Bauerfeind; Min Ae Lee-Kirsch; Andreas Arnold; Georg Homuth; Carsten O Schmidt; Elisabeth Mangold; Sven Cichon; Thomas Keil; Elke Rodríguez; Annette Peters; Andre Franke; Wolfgang Lieb; Natalija Novak; Regina Fölster-Holst; Momoko Horikoshi; Juha Pekkanen; Sylvain Sebert; Lise L Husemoen; Niels Grarup; Johan C de Jongste; Fernando Rivadeneira; Albert Hofman; Vincent Wv Jaddoe; Suzanne Gma Pasmans; Niels J Elbert; André G Uitterlinden; Guy B Marks; Philip J Thompson; Melanie C Matheson; Colin F Robertson; Janina S Ried; Jin Li; Xian Bo Zuo; Xiao Dong Zheng; Xian Yong Yin; Liang Dan Sun; Maeve A McAleer; Grainne M O'Regan; Caoimhe Mr Fahy; Linda E Campbell; Milan Macek; Michael Kurek; Donglei Hu; Celeste Eng; Dirkje S Postma; Bjarke Feenstra; Frank Geller; Jouke Jan Hottenga; Christel M Middeldorp; Pirro Hysi; Veronique Bataille; Tim Spector; Carla Mt Tiesler; Elisabeth Thiering; Badri Pahukasahasram; James J Yang; Medea Imboden; Scott Huntsman; Natàlia Vilor-Tejedor; Caroline L Relton; Ronny Myhre; Wenche Nystad; Adnan Custovic; Scott T Weiss; Deborah A Meyers; Cilla Söderhäll; Erik Melén; Carole Ober; Benjamin A Raby; Angela Simpson; Bo Jacobsson; John W Holloway; Hans Bisgaard; Jordi Sunyer; Nicole M Probst Hensch; L Keoki Williams; Keith M Godfrey; Carol A Wang; Dorret I Boomsma; Mads Melbye; Gerard H Koppelman; Deborah Jarvis; Wh Irwin McLean; Alan D Irvine; Xue Jun Zhang; Hakon Hakonarson; Christian Gieger; Esteban G Burchard; Nicholas G Martin; Liesbeth Duijts; Allan Linneberg; Marjo-Riitta Jarvelin; Markus M Noethen; Susanne Lau; Norbert Hübner; Young-Ae Lee; Mayumi Tamari; David A Hinds; Daniel Glass; Sara J Brown; Joachim Heinrich; David M Evans; Stephan Weidinger
Journal:  Nat Genet       Date:  2015-10-19       Impact factor: 38.330

Review 7.  Principles of genome folding into topologically associating domains.

Authors:  Quentin Szabo; Frédéric Bantignies; Giacomo Cavalli
Journal:  Sci Adv       Date:  2019-04-10       Impact factor: 14.136

8.  Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.

Authors:  Mariana L Stevens; Zhonghua Zhang; Elisabet Johansson; Samriddha Ray; Amrita Jagpal; Brandy P Ruff; Arjun Kothari; Hua He; Lisa J Martin; Hong Ji; Kathryn Wikenheiser-Brokamp; Matthew T Weirauch; Dorothy M Supp; Jocelyn M Biagini Myers; Gurjit K Khurana Hershey
Journal:  Nat Commun       Date:  2020-08-14       Impact factor: 14.919
  9 in total

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