BACKGROUND: Pregnancy and lactation may constitute radiation-sensitive reproductive periods due to rapid cell proliferation and concentration of radioiodine in the lactating breast. However, there are limited epidemiological data among women exposed to radiation during these periods. METHODS: We examined incidence of breast cancer in a cohort of 3214 women who were pregnant and/or lactating within 2 months (26 April to 30 June 1986) of the Chernobyl accident and residing in contaminated regions of Belarus. There were 33 breast cancers identified through linkage with the Belarusian National Cancer Registry. Breast cancer rates among women who were either pregnant and/or lactating were compared with population rates by calculating standardized incidence ratios (SIR) and 95% confidence intervals (CI) adjusting for attained age, oblast, urban/rural residence and calendar year. RESULTS: Among women who were lactating, we found a greater than 2-fold increased risk of breast cancer compared with the general population, SIR = 2.49 (95% CI: 1.55, 3.75). In contrast, women who were pregnant were not at increased risk (SIR = 0.84 95% CI: 0.46, 1.38). The SIR was highest in women who were exposed at a younger age and at the earliest time period since the accident, though stratified analyses had limited sample sizes. CONCLUSIONS: We found a significantly increased risk of breast cancer among women residing in contaminated areas of Belarus who were lactating at the time of the accident and may have had elevated exposure to radioiodine, when compared with the general population. Studies of breast cancer with individual radiation dose estimates among women exposed during lactation are warranted. Published by Oxford University Press on behalf of the International Epidemiological Association 2021. This work is written by a US Government employee and is in the public domain in the US.
BACKGROUND: Pregnancy and lactation may constitute radiation-sensitive reproductive periods due to rapid cell proliferation and concentration of radioiodine in the lactating breast. However, there are limited epidemiological data among women exposed to radiation during these periods. METHODS: We examined incidence of breast cancer in a cohort of 3214 women who were pregnant and/or lactating within 2 months (26 April to 30 June 1986) of the Chernobyl accident and residing in contaminated regions of Belarus. There were 33 breast cancers identified through linkage with the Belarusian National Cancer Registry. Breast cancer rates among women who were either pregnant and/or lactating were compared with population rates by calculating standardized incidence ratios (SIR) and 95% confidence intervals (CI) adjusting for attained age, oblast, urban/rural residence and calendar year. RESULTS: Among women who were lactating, we found a greater than 2-fold increased risk of breast cancer compared with the general population, SIR = 2.49 (95% CI: 1.55, 3.75). In contrast, women who were pregnant were not at increased risk (SIR = 0.84 95% CI: 0.46, 1.38). The SIR was highest in women who were exposed at a younger age and at the earliest time period since the accident, though stratified analyses had limited sample sizes. CONCLUSIONS: We found a significantly increased risk of breast cancer among women residing in contaminated areas of Belarus who were lactating at the time of the accident and may have had elevated exposure to radioiodine, when compared with the general population. Studies of breast cancer with individual radiation dose estimates among women exposed during lactation are warranted. Published by Oxford University Press on behalf of the International Epidemiological Association 2021. This work is written by a US Government employee and is in the public domain in the US.
Authors: Eero Pukkala; Ausra Kesminiene; Semion Poliakov; Anton Ryzhov; Vladimir Drozdovitch; Lina Kovgan; Pentti Kyyrönen; Irina V Malakhova; Liudmila Gulak; Elisabeth Cardis Journal: Int J Cancer Date: 2006-08-01 Impact factor: 7.396
Authors: Ali G Saad; Seena Kumar; Elaine Ron; Jay H Lubin; Jerzy Stanek; Kevin E Bove; Yuri E Nikiforov Journal: J Clin Endocrinol Metab Date: 2006-05-02 Impact factor: 5.958
Authors: R Cooke; M E Jones; D Cunningham; S J Falk; D Gilson; B W Hancock; S J Harris; A Horwich; P J Hoskin; T Illidge; D C Linch; T A Lister; H H Lucraft; J A Radford; A M Stevens; I Syndikus; M V Williams; A J Swerdlow Journal: Br J Cancer Date: 2013-05-07 Impact factor: 7.640