Pharmacokinetics of a single oral dose of ofloxacin in patients with renal failure.

Ten male patients with chronic renal failure and five healthy male volunteers were given a single oral dose of ofloxacin (200 mg). Serum concentrations of ofloxacin were determined by a microbiological assay. The pharmacokinetic parameters were obtained using an open one-compartment model. The study showed prolonged half-life and decreased elimination of ofloxacin in patients with renal failure. The median t1/2 of ofloxacin was prolonged in patients (38.5 h) compared with volunteers (17.8 h) (P less than 0.01). The median AUC0----infinity was increased in patients (58.45 micrograms/ml X h) compared to volunteers (17.34 micrograms/ml X h) (P less than 0.01). Also, the median Cl was decreased in patients (3.42 l/h) compared with volunteers (11.53 l/h) (P less than 0.01).