Literature DB >> 34676862

Cryptic halogenation reactions in natural product biosynthesis.

Sanjoy Adak1, Bradley S Moore1,2.   

Abstract

Covering: Up to December 2020Enzymatic halogenation reactions are essential for the production of thousands of halogenated natural products. However, in recent years, scientists discovered several halogenases that transiently incorporate halogen atoms in intermediate biosynthetic molecules to activate them for further chemical reactions such as cyclopropanation, terminal alkyne formation, C-/O-alkylation, biaryl coupling, and C-C rearrangements. In each case, the halogen atom is lost in the course of biosynthesis to the final product and is hence termed "cryptic". In this review, we provide an overview of our current knowledge of cryptic halogenation reactions in natural product biosynthesis.

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Year:  2021        PMID： 34676862      PMCID： PMC8542889          DOI： 10.1039/d1np00010a

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   15.111


  95 in total

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