Xi Li1, Sakthi Ponandai-Srinivasan2, Kutty Selva Nandakumar3,4, Susanne Fabre1, Ning Xu Landén5, Alain Mavon1, Ia Khmaladze1. 1. Oriflame Cosmetics AB; Skin Research Institute Stockholm Sweden. 2. Division of Obstetrics and Gynecology, Department of Women's and Children's Health Karolinska Institute, and Karolinska University Hospital Stockholm Sweden. 3. Southern Medical University, School of Pharmaceutical Sciences Guangzhou China. 4. Medical Inflammation Research, Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden. 5. Department of Medicine, Solna, Dermatology and Venereology, Centre of Molecular Medicine Karolinska Institutet Stockholm Sweden.
Abstract
BACKGROUND: In human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules/natural active ingredients to regulate miRNA expression for significant advances in skin health/care product development was recognized. AIM: To review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging/senescence. METHODS: Most of the cited articles were found through literature search on PubMed. The main search criteria was a keyword "skin" in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10 years. RESULTS: All results are summarized in Figure 1, and they are based on cited references. CONCLUSIONS: Thus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health.
BACKGROUND: In human skin, miRNAs have important regulatory roles and are involved in the development, morphogenesis, and maintenance by influencing cell proliferation, differentiation, immune regulation, and wound healing. MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules/natural active ingredients to regulate miRNA expression for significant advances in skin health/care product development was recognized. AIM: To review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging/senescence. METHODS: Most of the cited articles were found through literature search on PubMed. The main search criteria was a keyword "skin" in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10 years. RESULTS: All results are summarized in Figure 1, and they are based on cited references. CONCLUSIONS: Thus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health.
Authors: Peter Dynoodt; Pieter Mestdagh; Gert Van Peer; Jo Vandesompele; Karen Goossens; Luc J Peelman; Barbara Geusens; Reinhart M Speeckaert; Jo L W Lambert; Mireille J L Van Gele Journal: J Invest Dermatol Date: 2012-08-16 Impact factor: 8.551
Authors: Katharina Röck; Julia Tigges; Steffen Sass; Alexandra Schütze; Ana-Maria Florea; Anke C Fender; Florian J Theis; Jean Krutmann; Fritz Boege; Ellen Fritsche; Guido Reifenberger; Jens W Fischer Journal: J Invest Dermatol Date: 2014-09-29 Impact factor: 8.551
Authors: Junwang Xu; Wenjie Wu; Liping Zhang; Wanda Dorset-Martin; Michael W Morris; Marc E Mitchell; Kenneth W Liechty Journal: Diabetes Date: 2012-07-30 Impact factor: 9.461