Athanasios A Tsekouras1,2, Panos Macheras3,4. 1. Department of Chemistry, Laboratory of Physical Chemistry, National and Kapodistrian University of Athens, Athens, Greece. 2. PharmaInformatics Unit, Research Center ATHENA, Athens, Greece. 3. PharmaInformatics Unit, Research Center ATHENA, Athens, Greece. macheras@pharm.uoa.gr. 4. Faculty of Pharmacy, Laboratory of Biopharmaceutics Pharmacokinetics, National and Kapodistrian University of Athens, Athens, Greece. macheras@pharm.uoa.gr.