| Literature DB >> 34662545 |
Katieli da Silva Souza Campanholi1, Jéssica Bassi da Silva2, Vagner Roberto Batistela3, Renato Sonchini Gonçalves4, Rafaela Said Dos Santos2, Rodolfo Bento Balbinot5, Danielle Lazarin-Bidóia5, Marcos Luciano Bruschi2, Tânia Ueda Nakamura5, Celso Vataru Nakamura5, Wilker Caetano4.
Abstract
This study presents a phytotherapeutic emulsion-filled gel design composed of Pluronic® F127, Carbopol® C934P, and high level of copaiba oil-resin (PHY-ECO). Mathematical modeling and response surface methodology (RSM) were employed to access the optimal ratio between the oil and the polymer gel-matrix constituents. The chemometric approach showed robust mechanical and thermoresponsive properties for emulsion gel. The model predicts viscosity parameters at 35.0°C (skin temperature) from PHY-ECOs. Optimized PHY-ECOs were described by 18-20% (w/w) F127, 0.25% (w/w) C934P, and 15% (w/w) copaiba oil-resin, and showed interfacial layers properties that led to high physicochemical stability. Besides, it had thermal stimuli-responsive that led large viscosity range before and after skin administration, observed by oscillatory rheology. These behaviors give the optimized smart PHY-ECO high design potential to be used as a pharmaceutical platform for CO delivery, focusing on the anti-inflammatory therapy and skin wound care.Entities:
Keywords: Copaiba oil-resin; Emulgel; Emulsion-filled gel; Natural anti-inflammatory; Thermoresponsive; Wounds
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Year: 2021 PMID： 34662545 DOI： 10.1016/j.xphs.2021.10.003
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534