Literature DB >> 34661734

Current practice trends for lacrimal gland neurotoxin in the management of epiphora-a BOPSS survey.

Micheal A O'Rourke1, Paul S Cannon2.   

Abstract

PURPOSE: Injection of botulinum neurotoxin A (BoNTA) to the lacrimal gland (LG) offers a simple and effective treatment in the management of epiphora. However, there is little data on current practice trends or uptake as an alternative to surgery. This study assesses current practice trends of such treatment amongst BOPSS (British Oculoplastic Surgery Society) members.
METHODS: All consultant BOPSS members were invited to participate in a web-based survey which consisted of 5 questions, with a reminder invitation to participate. The role, dose, potential side effects, use as an alternative to surgical intervention, and impact on service delivery were assessed.
RESULTS: Fifty-one BOPSS consultants (43% uptake) completed the survey. Ninety percent of respondents were regularly using LG BoNTA in their management of epiphora. The main indicators for considering BoNTA use were medical comorbidities and elderly patients. The mean first treatment dose of Botox® was 3.6 units (SD 1.5). Diplopia and ptosis complications were always discussed in the consent for treatment in addition to dry eye. Twenty-five percent of surgeons reported doing less conjunctivo-dacryocystorhinostomies (cDCR) due to the availability of LG BoNTA. No respondents felt that the requirement for repeated BoNTA treatments was impacting on their service delivery.
CONCLUSION: Uptake of LG BoNTA in the management of epiphora is at a similar rate to all other available treatments. As a result, respondents are performing less surgical procedures, particularly cDCR in patients at higher surgical morbidity.
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Entities:  

Keywords:  Botulinum neurotoxin; Epiphora; Lacrimal gland; Lacrimation

Mesh:

Substances:

Year:  2021        PMID: 34661734     DOI: 10.1007/s00417-021-05457-w

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN: 0721-832X            Impact factor:   3.117


  24 in total

1.  An anatomical approach to problems of the eyelids and lacrimal apparatus.

Authors:  L T JONES
Journal:  Arch Ophthalmol       Date:  1961-07

2.  Duration of botulinum toxin effect in the treatment of crocodile tears.

Authors:  Angel Nava-Castañeda; Jose L Tovilla-Canales; Victor Boullosa; Jose L Tovilla-y-Pomar; Maria H Monroy-Serrano; Victor Tapia-Guerra; Yonathan Garfias
Journal:  Ophthalmic Plast Reconstr Surg       Date:  2006 Nov-Dec       Impact factor: 1.746

3.  Evaluating the effects of Botulinum Toxin A on tear metrics in patients with hemifacial spasm.

Authors:  Yasmin Poustchi Mali; Robert L Schultze; Edward J Wladis
Journal:  Orbit       Date:  2017-06-19

4.  Clinical research, comparison of the subjective visual function in patients with epiphora and patients with second-eye cataract.

Authors:  Namir Kafil-Hussain; Ramona Khooshebah
Journal:  Orbit       Date:  2005-03

5.  Botulinum toxin type a injection for lateral canthal rhytids : effect on tear film stability and tear production.

Authors:  Min-Chieh Ho; Wei-Cherng Hsu; Yi-Ting Hsieh
Journal:  JAMA Ophthalmol       Date:  2014-03       Impact factor: 7.389

6.  Results of lacrimal gland botulinum toxin injection for epiphora in lacrimal obstruction and gustatory tearing.

Authors:  Ted H Wojno
Journal:  Ophthalmic Plast Reconstr Surg       Date:  2011 Mar-Apr       Impact factor: 1.746

Review 7.  How botulinum and tetanus neurotoxins block neurotransmitter release.

Authors:  Y Humeau; F Doussau; N J Grant; B Poulain
Journal:  Biochimie       Date:  2000-05       Impact factor: 4.079

8.  Tear production and drainage after botulinum toxin A injection in patients with essential blepharospasm.

Authors:  Dae Il Park; Hyun Min Shin; Sang Yeul Lee; Helen Lew
Journal:  Acta Ophthalmol       Date:  2013-03       Impact factor: 3.761

9.  The use of botulinum toxin A in the treatment of functional epiphora.

Authors:  Karl W Whittaker; Bethan N Matthews; Alan W Fitt; S Sandramouli
Journal:  Orbit       Date:  2003-09

Review 10.  Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.

Authors:  Darlene A Dartt
Journal:  Prog Retin Eye Res       Date:  2009-04-17       Impact factor: 21.198

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