Literature DB >> 34661146

Promiscuous Structural Variants Drive Myeloma Initiation and Progression.

P Leif Bergsagel1, W Michael Kuehl2.   

Abstract

A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity. See related article by Rustad et al., p. 258. ©2020 American Association for Cancer Research.

Entities:  

Year:  2020        PMID： 34661146      PMCID： PMC8504774          DOI： 10.1158/2643-3230.BCD-20-0170

Source DB:  PubMed          Journal:  Blood Cancer Discov        ISSN： 2643-3230


  9 in total

1.  Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells.

Authors:  Brian A Walker; Christopher P Wardell; David C Johnson; Martin F Kaiser; Dil B Begum; Nasrin B Dahir; Fiona M Ross; Faith E Davies; David Gonzalez; Gareth J Morgan
Journal:  Blood       Date:  2013-02-22       Impact factor: 22.113

Review 2.  Criteria for inference of chromothripsis in cancer genomes.

Authors:  Jan O Korbel; Peter J Campbell
Journal:  Cell       Date:  2013-03-14       Impact factor: 41.582

3.  Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma.

Authors:  Y Shou; M L Martelli; A Gabrea; Y Qi; L A Brents; A Roschke; G Dewald; I R Kirsch; P L Bergsagel; W M Kuehl
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

4.  Punctuated evolution of prostate cancer genomes.

Authors:  Sylvan C Baca; Davide Prandi; Michael S Lawrence; Juan Miguel Mosquera; Alessandro Romanel; Yotam Drier; Kyung Park; Naoki Kitabayashi; Theresa Y MacDonald; Mahmoud Ghandi; Eliezer Van Allen; Gregory V Kryukov; Andrea Sboner; Jean-Philippe Theurillat; T David Soong; Elizabeth Nickerson; Daniel Auclair; Ashutosh Tewari; Himisha Beltran; Robert C Onofrio; Gunther Boysen; Candace Guiducci; Christopher E Barbieri; Kristian Cibulskis; Andrey Sivachenko; Scott L Carter; Gordon Saksena; Douglas Voet; Alex H Ramos; Wendy Winckler; Michelle Cipicchio; Kristin Ardlie; Philip W Kantoff; Michael F Berger; Stacey B Gabriel; Todd R Golub; Matthew Meyerson; Eric S Lander; Olivier Elemento; Gad Getz; Francesca Demichelis; Mark A Rubin; Levi A Garraway
Journal:  Cell       Date:  2013-04-25       Impact factor: 41.582

5.  Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma.

Authors:  P L Bergsagel; M Chesi; E Nardini; L A Brents; S L Kirby; W M Kuehl
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

6.  Frequent occurrence of large duplications at reciprocal genomic rearrangement breakpoints in multiple myeloma and other tumors.

Authors:  Yulia Demchenko; Anna Roschke; Wei-Dong Chen; Yan Asmann; Peter Leif Bergsagel; Walter Michael Kuehl
Journal:  Nucleic Acids Res       Date:  2016-06-27       Impact factor: 16.971

7.  Patterns of somatic structural variation in human cancer genomes.

Authors:  Yilong Li; Nicola D Roberts; Jeremiah A Wala; Ofer Shapira; Steven E Schumacher; Kiran Kumar; Ekta Khurana; Sebastian Waszak; Jan O Korbel; James E Haber; Marcin Imielinski; Joachim Weischenfeldt; Rameen Beroukhim; Peter J Campbell
Journal:  Nature       Date:  2020-02-05       Impact factor: 49.962

8.  Revealing the impact of structural variants in multiple myeloma.

Authors:  Ola Landgren; Francesco Maura; Even H Rustad; Venkata D Yellapantula; Dominik Glodzik; Kylee H Maclachlan; Benjamin Diamond; Eileen M Boyle; Cody Ashby; Patrick Blaney; Gunes Gundem; Malin Hultcrantz; Daniel Leongamornlert; Nicos Angelopoulos; Luca Agnelli; Daniel Auclair; Yanming Zhang; Ahmet Dogan; Niccolò Bolli; Elli Papaemmanuil; Kenneth C Anderson; Philippe Moreau; Hervé Avet-Loiseau; Nikhil C Munshi; Jonathan J Keats; Peter J Campbell; Gareth J Morgan
Journal:  Blood Cancer Discov       Date:  2020-09-15

9.  Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.

Authors:  P Leif Bergsagel; W Michael Kuehl; Maurizio Affer; Marta Chesi; Wei-Dong G Chen; Jonathan J Keats; Yulia N Demchenko; Anna V Roschke; Scott Van Wier; Rafael Fonseca
Journal:  Leukemia       Date:  2014-02-12       Impact factor: 11.528
  9 in total
  1 in total

Review 1.  Review of Multiple Myeloma Genetics including Effects on Prognosis, Response to Treatment, and Diagnostic Workup.

Authors:  Julia Erin Wiedmeier-Nutor; Peter Leif Bergsagel
Journal:  Life (Basel)       Date:  2022-05-30
  1 in total

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