Marijana Kovačević1,2, Snežana Mališ1,2, Dragana Pavlović1,2, Maksim Kovačević1,2, Ana Savić Radojević3, Ljubica Djukanović4. 1. University of East Sarajevo, Faculty of Medicine, Foča, Bosnia and Herzegovina. 2. Department for Internal Medicine, University Hospital, Foča, Bosnia and Herzegovina. 3. University of Belgrade, School of Medicine, Dr Subotića starijeg 8, 11 000, Belgrade, Serbia. 4. University of Belgrade, School of Medicine, Dr Subotića starijeg 8, 11 000, Belgrade, Serbia. ljubicadjukanovic@yahoo.com.
Abstract
INTRODUCTION: The aim of the study was to examine whether biomarkers of oxidative stress are predictors of diabetic nephropathy (DN) progression. METHODS: The study involved 45 patients with type 2 diabetes and DN and 15 healthy controls. Patients were followed for 3 years and the annual percentage change in eGFR was used to estimate the progression of DN. Patients with an annual percentage change in eGFR above the cutoff value of - 5.48%/year were classified in group 1, those with an annual percentage change in eGFR ≤ - 5.48%/year in group 2. RESULTS: The 28 patients in group 1 had the annual percentage change in eGFR of - 4.78 and 39.12%/year, and for the 17 patients in group 2 it ranged from - 24.86 to - 6.18%/year. At the onset of the study no significant differences were found between the groups in demographic, clinical or laboratory parameters. Plasma activities of glutathione peroxidase (GPX) and superoxide dismutase (SOD) were significantly lower in patients than in the controls. During 3-year study kidney function and size changed insignificantly in group 1, while eGFR and kidney size decreased and proteinuria increased significantly in group 2. Multivariate linear regression analysis selected male gender, duration of diabetes, systolic blood pressure, fasting serum glucose, urine protein/creatinine ratio as factors associated with DN progression. Plasma activity of GPX and SOD were selected as positive predictors of annual percentage change in eGFR. CONCLUSION: Besides already known factors, plasma activity of GPX and SOD were found to be significant independent predictors of DN progression.
INTRODUCTION: The aim of the study was to examine whether biomarkers of oxidative stress are predictors of diabetic nephropathy (DN) progression. METHODS: The study involved 45 patients with type 2 diabetes and DN and 15 healthy controls. Patients were followed for 3 years and the annual percentage change in eGFR was used to estimate the progression of DN. Patients with an annual percentage change in eGFR above the cutoff value of - 5.48%/year were classified in group 1, those with an annual percentage change in eGFR ≤ - 5.48%/year in group 2. RESULTS: The 28 patients in group 1 had the annual percentage change in eGFR of - 4.78 and 39.12%/year, and for the 17 patients in group 2 it ranged from - 24.86 to - 6.18%/year. At the onset of the study no significant differences were found between the groups in demographic, clinical or laboratory parameters. Plasma activities of glutathione peroxidase (GPX) and superoxide dismutase (SOD) were significantly lower in patients than in the controls. During 3-year study kidney function and size changed insignificantly in group 1, while eGFR and kidney size decreased and proteinuria increased significantly in group 2. Multivariate linear regression analysis selected male gender, duration of diabetes, systolic blood pressure, fasting serum glucose, urine protein/creatinine ratio as factors associated with DN progression. Plasma activity of GPX and SOD were selected as positive predictors of annual percentage change in eGFR. CONCLUSION: Besides already known factors, plasma activity of GPX and SOD were found to be significant independent predictors of DN progression.
Authors: Jay C Jha; Claudine Banal; Bryna S M Chow; Mark E Cooper; Karin Jandeleit-Dahm Journal: Antioxid Redox Signal Date: 2016-04-01 Impact factor: 8.401
Authors: Paul Lewis; Nada Stefanovic; Josefa Pete; Anna C Calkin; Sara Giunti; Vicki Thallas-Bonke; Karin A Jandeleit-Dahm; Terri J Allen; Ismail Kola; Mark E Cooper; Judy B de Haan Journal: Circulation Date: 2007-04-09 Impact factor: 29.690
Authors: Helen C Looker; Marco Colombo; Sibylle Hess; Mary J Brosnan; Bassam Farran; R Neil Dalton; Max C Wong; Charles Turner; Colin N A Palmer; Everson Nogoceke; Leif Groop; Veikko Salomaa; David B Dunger; Felix Agakov; Paul M McKeigue; Helen M Colhoun Journal: Kidney Int Date: 2015-07-22 Impact factor: 10.612