Andy Bush1, Ian D Pavord2. 1. Imperial Centre for Paediatrics and Child Health and Paediatric Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, UK; Royal Brompton and Harefield NHS Foundation Trust, London SW3 6NP, UK. Electronic address: a.bush@rbht.nhs.uk. 2. NIHR Respiratory Biomedical Research Centre and Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.