Literature DB >> 34653366

cAAVe phaenomena: Beware of appearances!

Filippo Calzolari1, Benedikt Berninger2.   

Abstract

In this issue of Cell, Wang et al. come to the unsettling conclusion that adeno-associated viruses, despite being engineered for glia-specific expression, can become widely active in endogenous neurons, misleading researchers in their quest for efficient conversion of glia into neurons for brain repair.
Copyright © 2021 Elsevier Inc. All rights reserved.

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Year:  2021        PMID: 34653366     DOI: 10.1016/j.cell.2021.09.027

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  2 in total

1.  Lineage tracing: The gold standard to claim direct reprogramming in vivo.

Authors:  Clive N Svendsen; Michael V Sofroniew
Journal:  Mol Ther       Date:  2022-02-04       Impact factor: 11.454

Review 2.  In vivo glia-to-neuron conversion: pitfalls and solutions.

Authors:  Lei-Lei Wang; Chun-Li Zhang
Journal:  Dev Neurobiol       Date:  2022-05-23       Impact factor: 3.102

  2 in total

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