Matteo Giaccherini1,2, Cosmeri Rizzato3, Manuel Gentiluomo1, Antonella Lupetti3, Lourdes Flores-Luna4, Jorge Vivas5, Maria Mercedes Bravo6, Elena Kasamatsu7, Nubia Muñoz8, Federico Canzian2, Ikuko Kato9, Daniele Campa1. 1. Department of Biology, University of Pisa, Pisa, Italy. 2. Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. 3. Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. 4. Medical Science Department, Center for Public Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico. 5. Cancer Control Center of the Tachira State, San Cristobal, Venezuela. 6. Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá, Colombia. 7. Department of Pathology, Instituto de Investigaciones en Ciencias de la Salud, National University of Asunción, Asunción, Paraguay. 8. Cancer Institute of Colombia, Bogotá, Colombia. 9. Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Abstract
BACKGROUND: Gastric cancer is worldwide the fourth more common cancer type by incidence, and the third by mortality. We analyzed three missense variants of TAS2R38 gene: rs713598 (A49P), rs1726866 (V262A), and rs10246939 (I296V). These variants and their combination in haplotypes (proline, alanine and valine/tasters or alanine, valine and isoleucine/nontasters) and diplotypes are responsible for individual differences in bitter perception. The single-nucleotide polymorphisms and the related phenotypes are known to be associated with susceptibility to Gram-negative bacterial infections, such as Helicobacter pylori , and with risk of various cancer types. An association between intermediate tasters (as defined by TAS2R38 diplotypes) and increased risk of gastric cancer was reported in a Korean population. METHODS: We analyzed 2616 individuals of Latin American origin, representing the whole spectrum of lesions from gastritis to gastric cancer. RESULTS: Comparing cancer cases vs. noncancers we observed a decrease in risk associated with heterozygous carriers of rs10246939 ( P = 0.006) and rs1726866 ( P = 0.003) when compared with homozygotes of the more common allele. Also, the analysis of diplotypes/phenotypes reflected the same association, with super-tasters showing a borderline increased risk of developing gastric cancer compared to medium-tasters [odds ratio (OR) = 1.63; 95% confidence interval (CI), 1.04-2.56; P = 0.033]. Also, nontasters showed an increased risk when compared to medium-tasters although not reaching statistical significance (OR = 1.58; 95% CI, 0.80-2.87; P = 0.203). We also tested the interactions between the TAS2R38 genotypes and H. pylori cagA status in a subset of samples and found no interaction. CONCLUSION: In conclusion, our results suggest only a modest contribution of TAS2R38 gene genetic variability in gastric cancer etiology.
BACKGROUND: Gastric cancer is worldwide the fourth more common cancer type by incidence, and the third by mortality. We analyzed three missense variants of TAS2R38 gene: rs713598 (A49P), rs1726866 (V262A), and rs10246939 (I296V). These variants and their combination in haplotypes (proline, alanine and valine/tasters or alanine, valine and isoleucine/nontasters) and diplotypes are responsible for individual differences in bitter perception. The single-nucleotide polymorphisms and the related phenotypes are known to be associated with susceptibility to Gram-negative bacterial infections, such as Helicobacter pylori , and with risk of various cancer types. An association between intermediate tasters (as defined by TAS2R38 diplotypes) and increased risk of gastric cancer was reported in a Korean population. METHODS: We analyzed 2616 individuals of Latin American origin, representing the whole spectrum of lesions from gastritis to gastric cancer. RESULTS: Comparing cancer cases vs. noncancers we observed a decrease in risk associated with heterozygous carriers of rs10246939 ( P = 0.006) and rs1726866 ( P = 0.003) when compared with homozygotes of the more common allele. Also, the analysis of diplotypes/phenotypes reflected the same association, with super-tasters showing a borderline increased risk of developing gastric cancer compared to medium-tasters [odds ratio (OR) = 1.63; 95% confidence interval (CI), 1.04-2.56; P = 0.033]. Also, nontasters showed an increased risk when compared to medium-tasters although not reaching statistical significance (OR = 1.58; 95% CI, 0.80-2.87; P = 0.203). We also tested the interactions between the TAS2R38 genotypes and H. pylori cagA status in a subset of samples and found no interaction. CONCLUSION: In conclusion, our results suggest only a modest contribution of TAS2R38 gene genetic variability in gastric cancer etiology.
Authors: N Muñoz; I Kato; S Peraza; G Lopez; E Carrillo; H Ramirez; J Vivas; D Castro; V Sanchez; O Andrade; E Buiatti; W Oliver Journal: Cancer Epidemiol Biomarkers Prev Date: 1996-01 Impact factor: 4.254
Authors: Joshua D Lambert; Sarah R VanDusen; Jennie E Cockroft; Elizabeth C Smith; Darren C Greenwood; Janet E Cade Journal: Eur J Nutr Date: 2018-07-06 Impact factor: 5.614
Authors: Eric J Duell; Catalina Bonet; Xavier Muñoz; Leila Lujan-Barroso; Elisabete Weiderpass; Marie-Christine Boutron-Ruault; Antoine Racine; Gianluca Severi; Federico Canzian; Cosmeri Rizzato; Heiner Boeing; Kim Overvad; Anne Tjønneland; Marcial Argüelles; Emilio Sánchez-Cantalejo; Saioa Chamosa; José María Huerta; Aurelio Barricarte; Kay-Tee Khaw; Nick Wareham; Rutch C Travis; Antonia Trichopoulou; Dimitrios Trichopoulos; Nikos Yiannakouris; Domenico Palli; Claudia Agnoli; Rosario Tumino; Alessio Naccarati; Salvatore Panico; H Bas Bueno-de-Mesquita; Peter D Siersema; Petra H M Peeters; Bodil Ohlsson; Björn Lindkvist; Ingegerd Johansson; Weimin Ye; Matthias Johansson; Claus Fenger; Elio Riboli; Núria Sala; Carlos A González Journal: Int J Cancer Date: 2014-07-01 Impact factor: 7.396