| Literature DB >> 34651217 |
Jessica Fernandes Ramos1,2, Gleice Leite3, Roberta Cristina Ruedas Martins4, Camila Rizek4, Sabri Saeed Al Sanabani5, Flavia Rossi6, Thais Guimarães1,4, Anna Sara Levin1,4, Vanderson Rocha2,7, Silvia Figueiredo Costa1,4.
Abstract
Bloodstream infection (BSI) caused by carbapenem-resistant P. aeruginosa (CRPA) has high mortality in hematopoietic stem cell transplant (HSCT) recipients. We performed MIC, checkerboard, time-kill assay, PFGE, PCR, and whole genome sequence and described the clinical outcome through Epi Info comparing the antimicrobial combination in vitro. Mortality was higher in BSI caused by CRPA carrying the lasB virulence gene. The isolates were 97% resistant to meropenem displaying synergistic effect to 57% in combination with colistin. Seventy-three percent of the isolates harbored blaSPM-1 and Tn4371 and belonged to ST277. The synergistic effect in vitro with meropenem with colistin appeared to be a better therapeutic option.Entities:
Keywords: Bloodstream infection; Carbapenem-resistant Pseudomonas aeruginosa; Multidrug resistance; Stem cell transplant; Synergism; Virulence
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Year: 2021 PMID： 34651217 DOI： 10.1007/s10096-021-04361-9
Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267