Jingnan Du1,2, Edmund T Rolls1,3,4, Weikang Gong5, Miao Cao1,2, Deniz Vatansever1,2, Jie Zhang1,2, Jujiao Kang1,2, Wei Cheng6,7,8, Jianfeng Feng1,2,3,9. 1. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. 2. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, 200433, China. 3. Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK. 4. Oxford Centre for Computational Neuroscience, Oxford, UK. 5. Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK. 6. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China. wcheng@fudan.edu.cn. 7. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, 200433, China. wcheng@fudan.edu.cn. 8. Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Jinhua, China. wcheng@fudan.edu.cn. 9. Fudan ISTBI-ZJNU Algorithm Centre for Brain-inspired Intelligence, Zhejiang Normal University, Jinhua, China.
Abstract
OBJECTIVE: To investigate the relation between parental age, and behavioral, cognitive and brain differences in the children. METHOD: Data with children aged 9-11 of 8709 mothers with parental age 15-45 years were analyzed from the Adolescent Brain Cognitive Development (ABCD) study. A general linear model was used to test the associations of the parental age with brain structure, and behavioral and cognitive problems scores. RESULTS: Behavioral and cognitive problems were greater in the children of the younger mothers, and were associated with lower volumes of cortical regions in the children. There was a linear correlation between the behavioral and cognitive problems scores, and the lower brain volumes (r > 0.6), which was evident when parental age was included as a stratification factor. The regions with lower volume included the anterior cingulate cortex, medial and lateral orbitofrontal cortex and amygdala, parahippocampal gyrus and hippocampus, and temporal lobe (FDR corrected p < 0.01). The lower cortical volumes and areas in the children significantly mediated the association between the parental age and the behavioral and cognitive problems in the children (all p < 10-4). The effects were large, such as the 71.4% higher depressive problems score, and 27.5% higher rule-breaking score, in the children of mothers aged 15-19 than the mothers aged 34-35. CONCLUSIONS: Lower parental age is associated with behavioral problems and reduced cognitive performance in the children, and these differences are related to lower volumes and areas of some cortical regions which mediate the effects in the children. The findings are relevant to psychiatric understanding and assessment.
OBJECTIVE: To investigate the relation between parental age, and behavioral, cognitive and brain differences in the children. METHOD: Data with children aged 9-11 of 8709 mothers with parental age 15-45 years were analyzed from the Adolescent Brain Cognitive Development (ABCD) study. A general linear model was used to test the associations of the parental age with brain structure, and behavioral and cognitive problems scores. RESULTS: Behavioral and cognitive problems were greater in the children of the younger mothers, and were associated with lower volumes of cortical regions in the children. There was a linear correlation between the behavioral and cognitive problems scores, and the lower brain volumes (r > 0.6), which was evident when parental age was included as a stratification factor. The regions with lower volume included the anterior cingulate cortex, medial and lateral orbitofrontal cortex and amygdala, parahippocampal gyrus and hippocampus, and temporal lobe (FDR corrected p < 0.01). The lower cortical volumes and areas in the children significantly mediated the association between the parental age and the behavioral and cognitive problems in the children (all p < 10-4). The effects were large, such as the 71.4% higher depressive problems score, and 27.5% higher rule-breaking score, in the children of mothers aged 15-19 than the mothers aged 34-35. CONCLUSIONS: Lower parental age is associated with behavioral problems and reduced cognitive performance in the children, and these differences are related to lower volumes and areas of some cortical regions which mediate the effects in the children. The findings are relevant to psychiatric understanding and assessment.
Authors: P Shaw; M Gilliam; M Malek; N Rodriguez; D Greenstein; L Clasen; A Evans; J Rapoport; J Giedd Journal: Cereb Cortex Date: 2011-08-04 Impact factor: 5.357
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