Literature DB >> 3464796

Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas.

K Sakai, S Mori, T Kawamoto, S Taniguchi, O Kobori, Y Morioka, T Kuroki, K Kano.   

Abstract

Tissues of normal human gastric mucosae and 15 advanced gastric carcinomas were studied immunohistologically for the presence of receptors for epidermal growth factor (EGF) by use of a murine monoclonal antibody (528IgG), which reacts with the binding domain of human EGF receptor. On normal gastric mucosae, only parietal cells showed positive staining. On cancer tissues, definite staining was observed in 9 of 15 cases. Their staining intensities were variable and weaker in general compared to those of either gastric parietal cells or normal tonsilar squamous epithelium. No apparent correlation of EGF receptor staining with the grade of histologic differentiation or lymph node metastases of these gastric carcinomas was noted.

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Year:  1986        PMID： 3464796

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  46 in total

1.  The effectiveness of trastuzumab (Herceptin) combined with chemotherapy for gastric carcinoma with overexpression of the c-erbB-2 protein.

Authors:  Christine Rebischung; Raphaëlle Barnoud; Laetitia Stéfani; Jean-Luc Faucheron; Mireille Mousseau
Journal:  Gastric Cancer       Date:  2005       Impact factor: 7.370

2.  Clinical Significance of HER2 Overexpression in Gastric and Gastroesophageal Junction Cancers.

Authors:  Meltem Baykara; Mustafa Benekli; Ozgur Ekinci; Sultan Cigdem Irkkan; Halit Karaca; Umut Demirci; Muhammed Bulent Akinci; Olcun Umit Unal; Faysal Dane; Fatma Paksoy Turkoz; Ozan Balakan; Eylem Pinar Eser; Selcuk Cemil Ozturk; Metin Ozkan; Berna Oksuzoglu; Alper Sevinc; Necla Demir; Hakan Harputluoglu; Bulent Yalcin; Ugur Coskun; Aytug Uner; Ahmet Ozet; Suleyman Buyukberber
Journal:  J Gastrointest Surg       Date:  2015-07-16       Impact factor: 3.452

3.  Epidermal growth factor receptor on human thyroid neoplasms.

Authors:  H Masuda; A Sugenoya; S Kobayashi; Y Kasuga; F Iida
Journal:  World J Surg       Date:  1988-10       Impact factor: 3.352

4.  Prognostic significance of HER2/neu expression in gastric cancer.

Authors:  Julian Ananiev; Maya Gulubova; Irena Manolova; Georgi Tchernev
Journal:  Wien Klin Wochenschr       Date:  2011-07-11       Impact factor: 1.704

Review 5.  Metastatic gastric cancer treatment: a little slow but worthy progress.

Authors:  Ozkan Kanat; Bert H O'Neil
Journal:  Med Oncol       Date:  2013-01-20       Impact factor: 3.064

6.  The prognostic impact of EGFR, ErbB2 and MET gene amplification in human gastric carcinomas as measured by quantitative Real-Time PCR.

Authors:  Ghasem Janbabai; Ziaeddin Oladi; Touraj Farazmandfar; Tarang Taghvaei; Farshad Naghshvar
Journal:  J Cancer Res Clin Oncol       Date:  2015-03-29       Impact factor: 4.553

Review 7.  The role of HER2 in cancer therapy and targeted drug delivery.

Authors:  Wanyi Tai; Rubi Mahato; Kun Cheng
Journal:  J Control Release       Date:  2010-04-10       Impact factor: 9.776

8.  Correlation between epidermal growth factor receptor concentration and the growth of human gastric cancer xenografts in nude mice.

Authors:  T Kiyama; M Onda; A Tokunaga; I Fujita; T Okuda; T Mizutani; T Yoshiyuki; Y Shimizu; K Nishi; N Matsukura
Journal:  Gastroenterol Jpn       Date:  1992-08

9.  Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs).

Authors:  E M Hiesiger; R L Hayes; D M Pierz; G N Budzilovich
Journal:  J Neurooncol       Date:  1993-05       Impact factor: 4.130

10.  HER2 Expression in Gastric and Gastroesophageal Cancer: Report from a Tertiary Care Hospital in North India.

Authors:  Mallika Tewari; Akhileshwar Kumar; R R Mishra; Mohan Kumar; Hari S Shukla
Journal:  Indian J Surg       Date:  2013-02-05       Impact factor: 0.656
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