Cristina Palacios1, Maria Angelica Trak-Fellermeier1, Marytere Melendez2, Maribel Campos3, Jeremy Pomeroy4, Kai Guo2, Paul W Franks5, Kaumudi Joshipura2. 1. Department of Dietetics and Nutrition. Robert Stempel College of Public Health & Social Work. Florida International University. 2. Center for Clinical Research and Health Promotion. Medical Sciences Campus. University of Puerto Rico. 3. Center for Community Outreach for Health Across the Lifespan, Dental and Craniofacial Genomics Core. Medical Sciences Campus. University of Puerto Rico. 4. Center for Clinical Epidemiology and Population Health. Marshfield Clinic Research Foundation. Marshfield Clinic Health System. 5. Genetic and Molecular Epidemiology Unit. Department of Clinical Sciences. Lunds Universitet. Skånes Universitetssjukhus i Malmö.
Abstract
INTRODUCTION: Objectives: low vitamin D during pregnancy is common and could adversely affect health outcomes. This study evaluated vitamin D status during pregnancy and early in life, and its association with glucose metabolism. Methods: maternal serum 25(OH)D, glucose, and insulin levels were measured longitudinally during pregnancy in Hispanic women with overweight/obesity (n = 31) and their infants at birth and 4 months. Results: insulin and HOMA-IR levels were higher among women with vitamin D below adequate levels compared to those with adequate levels in pregnancy (p < 0.05). Late in pregnancy, as vitamin D increased by one unit (ng/mL), insulin decreased by 0.44 units and HOMA-IR by 0.09 units. Maternal vitamin D late in pregnancy was correlated with infant vitamin D levels at birth (r = 0.89; p < 0.01) and 4 months (r = 0.9; p = 0.04), and with glucose (r = 0.79; p = 0.03) and insulin (r = 0.83; p = 0.04) at 4 months. Conclusion: maternal vitamin D status was associated with maternal and infant glucose metabolism in this sample.
INTRODUCTION: Objectives: low vitamin D during pregnancy is common and could adversely affect health outcomes. This study evaluated vitamin D status during pregnancy and early in life, and its association with glucose metabolism. Methods: maternal serum 25(OH)D, glucose, and insulin levels were measured longitudinally during pregnancy in Hispanic women with overweight/obesity (n = 31) and their infants at birth and 4 months. Results: insulin and HOMA-IR levels were higher among women with vitamin D below adequate levels compared to those with adequate levels in pregnancy (p < 0.05). Late in pregnancy, as vitamin D increased by one unit (ng/mL), insulin decreased by 0.44 units and HOMA-IR by 0.09 units. Maternal vitamin D late in pregnancy was correlated with infant vitamin D levels at birth (r = 0.89; p < 0.01) and 4 months (r = 0.9; p = 0.04), and with glucose (r = 0.79; p = 0.03) and insulin (r = 0.83; p = 0.04) at 4 months. Conclusion: maternal vitamin D status was associated with maternal and infant glucose metabolism in this sample.
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Keywords:
Vitamina D. Embarazo. Lactante. Glucosa. Insulina.
Authors: Caroline K Kramer; Balakumar Swaminathan; Anthony J Hanley; Philip W Connelly; Mathew Sermer; Bernard Zinman; Ravi Retnakaran Journal: J Clin Endocrinol Metab Date: 2014-12 Impact factor: 5.958
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