Literature DB >> 3464345

An apparent tandem quadruplication of chromosome 21 in a case of childhood acute lymphoblastic leukemia.

I D Dubé, H el-Solh.   

Abstract

A case of childhood ALL is presented in which the leukemic clone had both normal chromosomes #21 replaced by a single marker chromosome that contained four copies of chromosome #21 arranged in tandem. This unique report further emphasizes the role played by multiple copies of chromosome #21 in acute leukemia. The observation of one cell in which the marker appeared to consist of only three copies of chromosome #21 arranged in tandem raises the possibility that the marker chromosome arose as a result of a stepwise amplification process.

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Year:  1986        PMID： 3464345     DOI： 10.1016/0165-4608(86)90185-8

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  1 in total

1.  An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome.

Authors:  C J Harrison; A V Moorman; C Schwab; A J Carroll; E A Raetz; M Devidas; S Strehl; K Nebral; J Harbott; A Teigler-Schlegel; M Zimmerman; N Dastuge; A Baruchel; J Soulier; M-F Auclerc; A Attarbaschi; G Mann; B Stark; G Cazzaniga; L Chilton; P Vandenberghe; E Forestier; I Haltrich; S C Raimondi; M Parihar; J-P Bourquin; J Tchinda; C Haferlach; A Vora; S P Hunger; N A Heerema; O A Haas
Journal:  Leukemia       Date:  2013-10-29       Impact factor: 11.528
  1 in total

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