Literature DB >> 34642086

Orexin (hypocretin) and addiction.

Jacqueline B Mehr1, Michelle M Bilotti1, Morgan H James2.   

Abstract

Although originally implicated in appetite and sleep/wakefulness, the hypothalamic orexin (hypocretin) system has now been demonstrably linked with motivated behavior. This highly plastic system responds to reward-associated environmental stimuli and becomes pathologically overactive in addicted states. Here, we provide a brief overview of the roles of the orexin system in reward-seeking and addiction, as well as potential therapeutic opportunities for substance use disorders based on normalizing orexin function.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  dopamine; hypothalamus; plasticity; reward; substance use disorder

Mesh：

Substances：

Year:  2021        PMID： 34642086      PMCID： PMC8772282          DOI： 10.1016/j.tins.2021.09.002

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  12 in total

1.  Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats.

Authors:  Morgan H James; Colin M Stopper; Benjamin A Zimmer; Nikki E Koll; Hannah E Bowrey; Gary Aston-Jones
Journal:  Biol Psychiatry       Date:  2018-08-07       Impact factor: 13.382

Review 2.  A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?

Authors:  Morgan H James; Stephen V Mahler; David E Moorman; Gary Aston-Jones
Journal:  Curr Top Behav Neurosci       Date:  2017

3.  The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.

Authors:  L de Lecea; T S Kilduff; C Peyron; X Gao; P E Foye; P E Danielson; C Fukuhara; E L Battenberg; V T Gautvik; F S Bartlett; W N Frankel; A N van den Pol; F E Bloom; K M Gautvik; J G Sutcliffe
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

4.  Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Authors:  T Sakurai; A Amemiya; M Ishii; I Matsuzaki; R M Chemelli; H Tanaka; S C Williams; J A Richardson; G P Kozlowski; S Wilson; J R Arch; R E Buckingham; A C Haynes; S A Carr; R S Annan; D E McNulty; W S Liu; J A Terrett; N A Elshourbagy; D J Bergsma; M Yanagisawa
Journal:  Cell       Date:  1998-02-20       Impact factor: 41.582

5.  A role for lateral hypothalamic orexin neurons in reward seeking.

Authors:  Glenda C Harris; Mathieu Wimmer; Gary Aston-Jones
Journal:  Nature       Date:  2005-08-14       Impact factor: 49.962

6.  Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss.

Authors:  Ronald McGregor; Ling Shan; Ming-Fung Wu; Jerome M Siegel
Journal:  PLoS One       Date:  2017-06-01       Impact factor: 3.240

7.  NIDA's medication development priorities in response to the Opioid Crisis: ten most wanted.

Authors:  Kurt Rasmussen; David A White; Jane B Acri
Journal:  Neuropsychopharmacology       Date:  2018-12-07       Impact factor: 7.853

8.  Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy.

Authors:  Thomas C Thannickal; Joshi John; Ling Shan; Dick F Swaab; Ming-Fung Wu; Lalini Ramanathan; Ronald McGregor; Keng-Tee Chew; Marcia Cornford; Akihiro Yamanaka; Ayumu Inutsuka; Rolf Fronczek; Gert Jan Lammers; Paul F Worley; Jerome M Siegel
Journal:  Sci Transl Med       Date:  2018-06-27       Impact factor: 17.956

9.  Reduced number of hypocretin neurons in human narcolepsy.

Authors:  T C Thannickal; R Y Moore; R Nienhuis; L Ramanathan; S Gulyani; M Aldrich; M Cornford; J M Siegel
Journal:  Neuron       Date:  2000-09       Impact factor: 17.173

10.  Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states.

Authors:  William J Giardino; Ada Eban-Rothschild; Daniel J Christoffel; Shi-Bin Li; Robert C Malenka; Luis de Lecea
Journal:  Nat Neurosci       Date:  2018-07-23       Impact factor: 24.884
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  7 in total

Review 1.  Sleep-mediated regulation of reward circuits: implications in substance use disorders.

Authors:  Rong Guo; Dylan Thomas Vaughan; Ana Lourdes Almeida Rojo; Yanhua H Huang
Journal:  Neuropsychopharmacology       Date:  2022-06-16       Impact factor: 7.853

2.  Reduction of Orexin-A Is Associated With Anxiety and the Level of Depression of Male Methamphetamine Users During the Initial Withdrawal Period.

Authors:  Lei Guo; Aqian Hu; Xiaoxi Zhao; Xiaojun Xiang
Journal:  Front Psychiatry       Date:  2022-07-04       Impact factor: 5.435

3.  Dual Orexin Receptor Antagonists (DORAs) as an Adjunct Treatment for Smoking Cessation.

Authors:  Ajna Hamidovic
Journal:  CNS Drugs       Date:  2022-04-22       Impact factor: 6.497

4.  Orexin (Hypocretin) Signaling in the Basolateral Amygdala Contributes to Individual Differences in Stress Sensitivity.

Authors:  Utsav Gyawali; Morgan H James
Journal:  Biol Psychiatry       Date:  2022-05-01       Impact factor: 12.810

Review 5.  Physiological Role of Orexinergic System for Health.

Authors:  Ines Villano; Marco La Marra; Girolamo Di Maio; Vincenzo Monda; Sergio Chieffi; Ezia Guatteo; Giovanni Messina; Fiorenzo Moscatelli; Marcellino Monda; Antonietta Messina
Journal:  Int J Environ Res Public Health       Date:  2022-07-08       Impact factor: 4.614

6.  Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking.

Authors:  Giuseppe Giannotti; Francesca Mottarlini; Jasper A Heinsbroek; Mitchel R Mandel; Morgan H James; Jamie Peters
Journal:  Transl Psychiatry       Date:  2022-10-04       Impact factor: 7.989

Review 7.  Avian Orexin: Feed Intake Regulator or Something Else?

Authors:  Alison Ramser; Sami Dridi
Journal:  Vet Sci       Date:  2022-03-03
  7 in total

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