Literature DB >> 3463984

Inhibition of the in vivo parathyroid hormone-mediated calcemic response in rats by a synthetic hormone antagonist.

S H Doppelt, R M Neer, S R Nussbaum, P Federico, J T Potts, M Rosenblatt.   

Abstract

The parathyroid hormone (PTH) analog, [Tyr34]bovine PTH-(7-34)-amide, can inhibit the PTH-mediated elevation of plasma calcium in thyroparathyroidectomized rats in vivo. The analog is devoid of PTH-like agonist activity in this system. Repeated doses of analog inhibit the animal's calcemic response to PTH. The elevation in serum calcium levels mediated by PTH in this assay reflects PTH action (calcium mobilization) on bone. Earlier studies demonstrated antagonist properties of the analog in a renal-based assay; PTH-stimulated increases in urinary phosphate and cyclic AMP excretion were completely inhibited by the synthetic analog. Along with previous studies, this report indicates that [Tyr34]bovine PTH-(7-34)-amide is an effective in vivo antagonist for several major parameters of PTH action in both kidney and bone.

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Year:  1986        PMID： 3463984      PMCID： PMC386758          DOI： 10.1073/pnas.83.19.7557

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Parathyroid hormone inhibitors: comparison of biological activity in bone- and skin-derived tissue.

Authors:  S R Goldring; J E Mahaffey; M Rosenblatt; J M Dayer; J T Potts; S M Krane
Journal:  J Clin Endocrinol Metab       Date:  1979-04       Impact factor: 5.958

2.  Analysis of the requirements for parathyroid hormone action in renal membranes with the use of inhibiting analogues.

Authors:  D Goltzman; D Goltzmann; A Peytremann; E Callahan; G W Tregear; J T Potts
Journal:  J Biol Chem       Date:  1975-04-25       Impact factor: 5.157

3.  Identification of a receptor-binding region in parathyroid hormone.

Authors:  M Rosenblatt; G V Segre; G A Tyler; G L Shepard; S R Nussbaum; J T Potts
Journal:  Endocrinology       Date:  1980-08       Impact factor: 4.736

4.  Synthesis, purification, and chemical characterization of the amino-terminal 1-34 fragment of bovine parathyroid hormone synthesized by the solid-phase procedure.

Authors:  G W Tregear; J van Rietschoten; R Sauer; H D Niall; H T Keutmann; J T Potts
Journal:  Biochemistry       Date:  1977-06-28       Impact factor: 3.162

Review 5.  Solid-phase peptide synthesis.

Authors:  R B Merrifield
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1969

6.  Bovine parathyroid hormone: minimum chain length of synthetic peptide required for biological activity.

Authors:  G W Tregear; J Van Rietschoten; E Greene; H T Keutmann; H D Niall; B Reit; J A Parsons; J T Potts
Journal:  Endocrinology       Date:  1973-12       Impact factor: 4.736

7.  Parathyroid hormone . renal receptor interactions. Demonstration of two receptor-binding domains.

Authors:  S R Nussbaum; M Rosenblatt; J T Potts
Journal:  J Biol Chem       Date:  1980-11-10       Impact factor: 5.157

8.  Human parathyroid hormone 1-34-mediated hypercalcemia in a rat model, and its inhibition by dichloromethane diphosphonate.

Authors:  S H Doppelt; R M Neer; J T Potts
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

9.  Chemical and biological properties of synthetic, sulfur-free analogues of parathyroid hormone.

Authors:  M Rosenblatt; D Goltzman; H T Keutmann; G W Tregear; J T Potts
Journal:  J Biol Chem       Date:  1976-01-10       Impact factor: 5.157

10.  Biological activities of synthetic human parathyroid hormone (PTH) 1-84 relative to natural bovine 1-84 PTH in two different in vivo bioassay systems.

Authors:  J M Zanelli; E Lane; T Kimura; S Sakakibara
Journal:  Endocrinology       Date:  1985-11       Impact factor: 4.736
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  4 in total

1.  Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.

Authors:  A F Stewart; M Mangin; T Wu; D Goumas; K L Insogna; W J Burtis; A E Broadus
Journal:  J Clin Invest       Date:  1988-02       Impact factor: 14.808

2.  Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.

Authors:  Ross W Cheloha; Tomoyuki Watanabe; Thomas Dean; Samuel H Gellman; Thomas J Gardella
Journal:  ACS Chem Biol       Date:  2016-08-17       Impact factor: 5.100

Review 3.  PTH receptor-1 signalling-mechanistic insights and therapeutic prospects.

Authors:  Ross W Cheloha; Samuel H Gellman; Jean-Pierre Vilardaga; Thomas J Gardella
Journal:  Nat Rev Endocrinol       Date:  2015-08-25       Impact factor: 43.330

4.  Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2.

Authors:  Xi Wang; Xi Cheng; Lihua Zhao; Yuzhe Wang; Chenyu Ye; Xinyu Zou; Antao Dai; Zhaotong Cong; Jian Chen; Qingtong Zhou; Tian Xia; Hualiang Jiang; H Eric Xu; Dehua Yang; Ming-Wei Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2021-08-10       Impact factor: 11.205
  4 in total

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