A Wollenberg1, L A Beck2, M de Bruin Weller3, E L Simpson4, S Imafuku5, M Boguniewicz6, R Zachariae7, C K Olsen7, J P Thyssen8. 1. Klinikum der Universität München, Klinik und Poliklinik für Dermatologie und Allergologie, Munich, Germany. 2. Department of Dermatology, Medicine and Pathology, University of Rochester Medical Center, Rochester, NY, USA. 3. Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, the Netherlands. 4. Department of Dermatology, Oregon Health & Science University, Portland, OR, USA. 5. Department of Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan. 6. Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health, Denver, CO, USA. 7. LEO Pharma A/S, Ballerup, Denmark. 8. Department of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Abstract
BACKGROUND: Tralokinumab, a fully human IgG4 monoclonal antibody that specifically binds with high affinity to interleukin-13, effectively reduces moderate-to-severe atopic dermatitis (AD) when given every 2 weeks. The incidence of conjunctivitis is elevated vs. placebo, but severity and aetiology have not been examined. OBJECTIVE: To analyse conjunctivitis data recorded in five randomized, placebo-controlled trials of tralokinumab in adult patients with moderate-to-severe AD. METHODS: Overall, 2285 adults with AD were studied up to 16 weeks. Cochran-Mantel-Haenszel weights were applied to calculate the adjusted incidence of adverse events. RESULTS: The incidence of conjunctivitis was higher (7·5%) with tralokinumab than with placebo (3·2%). Most events were mild or moderate in severity, and 78·6% and 73·9% of events resolved during the trial in the tralokinumab and placebo groups, respectively. Two (1·4%) events led to the permanent discontinuation of tralokinumab. An increased incidence of conjunctivitis, regardless of treatment group, was associated with more severe baseline AD, and history of allergic conjunctivitis/atopic keratoconjunctivitis, as well as the number of atopic comorbidities. LIMITATIONS: This analysis reports events up to week 16 only, with limited confirmation of conjunctivitis and its aetiology by an ophthalmologist, and insufficient reporting of ophthalmic treatments. CONCLUSIONS: Treatment with tralokinumab was associated with an increased incidence of conjunctivitis vs. placebo, but these cases were mostly mild and transient.
BACKGROUND: Tralokinumab, a fully human IgG4 monoclonal antibody that specifically binds with high affinity to interleukin-13, effectively reduces moderate-to-severe atopic dermatitis (AD) when given every 2 weeks. The incidence of conjunctivitis is elevated vs. placebo, but severity and aetiology have not been examined. OBJECTIVE: To analyse conjunctivitis data recorded in five randomized, placebo-controlled trials of tralokinumab in adult patients with moderate-to-severe AD. METHODS: Overall, 2285 adults with AD were studied up to 16 weeks. Cochran-Mantel-Haenszel weights were applied to calculate the adjusted incidence of adverse events. RESULTS: The incidence of conjunctivitis was higher (7·5%) with tralokinumab than with placebo (3·2%). Most events were mild or moderate in severity, and 78·6% and 73·9% of events resolved during the trial in the tralokinumab and placebo groups, respectively. Two (1·4%) events led to the permanent discontinuation of tralokinumab. An increased incidence of conjunctivitis, regardless of treatment group, was associated with more severe baseline AD, and history of allergic conjunctivitis/atopic keratoconjunctivitis, as well as the number of atopic comorbidities. LIMITATIONS: This analysis reports events up to week 16 only, with limited confirmation of conjunctivitis and its aetiology by an ophthalmologist, and insufficient reporting of ophthalmic treatments. CONCLUSIONS: Treatment with tralokinumab was associated with an increased incidence of conjunctivitis vs. placebo, but these cases were mostly mild and transient.
Authors: Andrew Blauvelt; Melinda Gooderham; Neal Bhatia; Richard G Langley; Shannon Schneider; John Zoidis; Azra Kurbasic; April Armstrong; Jonathan I Silverberg Journal: Dermatol Ther (Heidelb) Date: 2022-09-24
Authors: Pernille M Hansen; Maxim A X Tollenaere; Anne Hedengran; Steffen Heegaard; Petra Amoudruz; Mads Røpke; Jacob P Thyssen; Miriam Kolko; Hanne Norsgaard Journal: Allergy Date: 2022-05-06 Impact factor: 14.710