Literature DB >> 346366

A preliminary study on the behaviour and biochemical responses subsequent to the injection of 5,6-dihydroxytryptamine into the substantia nigra of the rat.

N N Osborne, V Neuhoff, K H Sontag, S Wolfarth.   

Abstract

Injection of 5,7-dihydroxytryptamine into the substantia nigra of rats produces an increase of dopamine in the ipsilateral striatum, and when these animals are injected with amphetamine they do not exhibit any rotation. The mode of action of this neurotoxin is compared with that of 6-hydroxydopamine.

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Year:  1978        PMID： 346366     DOI： 10.1007/bf01935949

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  5,7-Dihydroxytryptamine: improvement of its selectivity for serotonin neurons in the CNS by pretreatment with desipramine.

Authors:  A Björklund; H G Baumgarten; A Rensch
Journal:  J Neurochem       Date:  1975-04       Impact factor: 5.372

2.  A rapid radiochemical method for the determination of choline acetyltransferase.

Authors:  F Fonnum
Journal:  J Neurochem       Date:  1975-02       Impact factor: 5.372

3.  Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.

Authors:  U Ungerstedt
Journal:  Acta Physiol Scand Suppl       Date:  1971

4.  Evaluation of the effects of 5,7-dihydroxytryptamine on serotonin and catecholamine neurons in the rat CNS.

Authors:  H G Baumgarten; A Björklund; L Lachenmayer; A Nobin
Journal:  Acta Physiol Scand Suppl       Date:  1973

5.  Chemical and electrical stimulation of the caudate nucleus in freely moving cats: the role of dopamine.

Authors:  A R Cools
Journal:  Brain Res       Date:  1973-08-30       Impact factor: 3.252

6.  The influence of microelectrophoretically applied biogenic amines, cholinomimetics and procaine on synaptic excitation in the corpus striatum.

Authors:  A Herz; W Zieglgänsberger
Journal:  Int J Neuropharmacol       Date:  1968-05

Review 7.  Experimental basis of the therapy of Parkinson's disease and the cholinergic-dopaminergic equilibrium in basal brain nuclei.

Authors:  S Wolfarth
Journal:  Pol J Pharmacol Pharm       Date:  1976

8.  Evidence for the existence of a raphe projection to the substantia nigra in rat.

Authors:  A Dray; T J Gonye; N R Oakley; T Tanner
Journal:  Brain Res       Date:  1976-08-20       Impact factor: 3.252

9.  The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography.

Authors:  P Bobillier; S Seguin; F Petitjean; D Salvert; M Touret; M Jouvet
Journal:  Brain Res       Date:  1976-09-03       Impact factor: 3.252

10.  Effects of drugs acting on cerebral 5-hydroxytryptamine mechanisms on dopamine-dependent turning behaviour in mice.

Authors:  J A Milson; C J Pycock
Journal:  Br J Pharmacol       Date:  1976-01       Impact factor: 8.739
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