Literature DB >> 3463623

The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectants.

D Landias, B N Beck, J M Buerstedde, S Degraw, D Klein, N Koch, D Murphy, M Pierres, T Tada, K Yamamoto.   

Abstract

The chain specificities of 18 Ak and 26 Ab-reactive anti-Ia monoclonal antibodies have been determined. L cells were transfected with haplotype-matched (A alpha k:A beta k, A alpha b:A beta k) or haplotype-mismatched (A alpha k:A beta b, A alpha b:A beta k) cDNA pairs, lines expressing high levels of surface A complex were selected, and antibody reactivity with a panel of reagents was assessed by cytofluorimetric analysis. Most of the antibodies recognized a determinant specified by one chain, either alpha or (more commonly) beta. A few examples of more complex determinants were also observed. A knowledge of the chain specificities of anti-Ia monoclonal antibodies should prove useful for a variety of studies aimed at dissecting Ia structure-function relationships.

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Year:  1986        PMID： 3463623

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  30 in total

1.  Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.

Authors:  C A Nelson; R W Roof; D W McCourt; E R Unanue
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

2.  Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

Authors:  C Layet; R N Germain
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

3.  Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

Authors:  S Suematsu; T Matsusaka; T Matsuda; S Ohno; J Miyazaki; K Yamamura; T Hirano; T Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

4.  Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.

Authors:  S Tourne; T Miyazaki; P Wolf; H Ploegh; C Benoist; D Mathis
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

5.  Haplotype-specific differences in signaling by transfected class II molecules to a Ly-1+ B-cell clone.

Authors:  G A Bishop; J A Frelinger
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

6.  Auto-delayed-type hypersensitivity induced in immunodeficient mice with modified self-antigens. V. Cellular autoreactivity directed against self-H-2Dd subregion mediates the inflammatory responses.

Authors:  N Tarcic; C S David; D Naor
Journal:  Immunology       Date:  1989-06       Impact factor: 7.397

7.  The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo.

Authors:  S Gilfillan; S Aiso; S A Michie; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

8.  A triad of molecular regions contribute to the formation of two distinct MHC class II conformers.

Authors:  Lisa A Drake; James R Drake
Journal:  Mol Immunol       Date:  2016-05-02       Impact factor: 4.407

9.  Human CD4 restores normal T cell development and function in mice deficient in murine CD4.

Authors:  Y M Law; R S Yeung; C Mamalaki; D Kioussis; T W Mak; R A Flavell
Journal:  J Exp Med       Date:  1994-04-01       Impact factor: 14.307

10.  Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

Authors:  S Guerder; D E Picarella; P S Linsley; R A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205
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