| Literature DB >> 34635798 |
Junya Kanda1, Hiromi Hayashi2,3,4, Annalisa Ruggeri3,4,5, Fumihiko Kimura6, Fernanda Volt3,4, Satoshi Takahashi7, Shinichi Kako8, Karina Tozatto-Maio3,4,9, Masamitsu Yanada10, Guillermo Sanz11, Naoyuki Uchida12, Emanuele Angelucci13, Seiko Kato14, Mohamad Mohty15,16, Edouard Forcade17, Masatsugu Tanaka18, Jorge Sierra19, Takanori Ohta20, Riccardo Saccardi21, Takahiro Fukuda22, Tatsuo Ichinohe23, Takafumi Kimura24, Vanderson Rocha3,4, Shinichiro Okamoto25, Arnon Nagler26,27, Yoshiko Atsuta28, Eliane Gluckman3,4.
Abstract
The impact of GVHD and graft-versus-leukemia effect in unrelated cord blood transplantation (UCBT) is controversial. In the Eurocord/ALWP EBMT and JSTCT/JDCHCT collaborative study, we evaluated the impact of GVHD on UCBT outcomes in Japanese and European registries. A total of 3,690 adult patients with acute leukemia who received their first single UCBT were included. A multivariate analysis of overall survival (OS) revealed a positive impact of grade II acute GVHD compared with grade 0-I GVHD, in the Japanese cohort (hazard ratio (HR), 0.81; P = 0.001), and an adverse impact in the European cohort (HR, 1.37; P = 0.007). A negative impact of grade III-IV acute GVHD on OS was observed regardless of registries. In the analysis of relapse, a positive impact of grade II acutes GVHD compared with grade 0-I GVHD was observed only in the Japanese cohort, regardless of disease risk. The positive impact of limited chronic GVHD on OS was observed only in the Japanese cohort. In conclusion, a positive impact of mild GVHD after a single UCBT was observed only in the Japanese cohort. This could explain the ethnic difference in UCBT outcomes and might contribute to the preference usage of UCBT in Japan.Entities:
Mesh：
Year: 2021 PMID： 34635798 DOI： 10.1038/s41409-021-01479-4
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483