Literature DB >> 3463509

Regulated expression of cloned human fetal A gamma-globin genes introduced into murine erythroleukemia cells.

P Charnay, L Henry.   

Abstract

We have analysed the expression of cloned human fetal gamma-globin genes introduced into murine erythroleukemia cells by a protoplast fusion procedure. Both the wild-type a gamma-globin gene and a mutant derivative related to a phenotype of hereditary persistence of fetal hemoglobin were studied. In both cases the level of gamma-globin mRNA increased by a factor of approximately sevenfold when erythroid cell differentiation was induced by treatment with hexamethylenebisacetamide. Thus, the regulation of the expression of the cloned fetal A gamma-globin gene in murine erythroleukemia cells resembled that of cloned adult beta-globin genes.

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Year:  1986        PMID： 3463509     DOI： 10.1111/j.1432-1033.1986.tb09910.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  7 in total

1.  A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.

Authors:  B Sorrentino; P Ney; D Bodine; A W Nienhius
Journal:  Nucleic Acids Res       Date:  1990-05-11       Impact factor: 16.971

2.  A fetal globin gene mutation in A gamma nondeletion hereditary persistence of fetal hemoglobin increases promoter strength in a nonerythroid cell.

Authors:  M W Rixon; R E Gelinas
Journal:  Mol Cell Biol       Date:  1988-02       Impact factor: 4.272

3.  Expression of the affected A gamma globin gene associated with Greek nondeletion hereditary persistence of fetal hemoglobin.

Authors:  C J Stoeckert; J E Metherall; M Yamakawa; J M Eisenstadt; S M Weissman; B G Forget
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

4.  Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines.

Authors:  K R Peterson; G Zitnik; C Huxley; C H Lowrey; A Gnirke; K A Leppig; T Papayannopoulou; G Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

5.  Increased erythroid-specific expression of a mutated HPFH gamma-globin promoter requires the erythroid factor NFE-1.

Authors:  S Nicolis; A Ronchi; N Malgaretti; R Mantovani; B Giglioni; S Ottolenghi
Journal:  Nucleic Acids Res       Date:  1989-07-25       Impact factor: 16.971

6.  An erythroid specific nuclear factor binding to the proximal CACCC box of the beta-globin gene promoter.

Authors:  R Mantovani; N Malgaretti; S Nicolis; B Giglioni; P Comi; N Cappellini; M T Bertero; F Caligaris-Cappio; S Ottolenghi
Journal:  Nucleic Acids Res       Date:  1988-05-25       Impact factor: 16.971

7.  The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

Authors:  G Superti-Furga; A Barberis; G Schaffner; M Busslinger
Journal:  EMBO J       Date:  1988-10       Impact factor: 11.598
  7 in total

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