Mohammad Javad Tavallaei1, Amir Hossein Tavallaei2, Narges Ebrahimi3, Hamed Ghoshouni4, Alireza Afshari-Safavi5, Shervin Badihian6, Vahid Shaygannejad7, Omid Mirmosayyeb8. 1. School of medicine, Iran university of medical sciences, Tehran, Iran. 2. School of medicine, Tehran University of medical sciences, Tehran, Iran. 3. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 4. School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 5. Department of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran. 6. Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 7. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran. 8. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: omid.mirmosayyeb@gmail.com.
Abstract
BACKGROUND: People with multiple sclerosis (PwMS) are suggested to have a higher death rate compared to the overall population. Increased risk and incidence of cardiovascular diseases is a possible contributing factor here, as these patients are suggested to be more prone to early death due to myocardial infarction (MI). AIM: This systematic review aims to describe the prevalence of MI among PwMS in comparison to the non-MS population. METHOD: We thoroughly searched for publications reporting the prevalence of MI among PwMS in PubMed, Scopus, Embase, and Web of Science. We excluded studies focusing on the following conditions: ischemic heart disease only, autopsy of PwMS, MS patients with a previous history of cardiovascular diseases, and MS diagnosed after MI. Moreover, we excluded reviews, editorials, and commentaries. We used the random effect model to calculate the pooled prevalence. RESULTS: We included nineteen studies, comprising 44 to 66616 participants. The overall prevalence of MI was 1.7% among PwMS. The pooled odds ratio estimate for MI was 1.41 in PwMS compared to the MS-free population. CONCLUSIONS: Results of this systematic review confirms the increased risk of MI among PwMS. Consequently, cardiovascular diseases should be considered in the management of these patients.
BACKGROUND: People with multiple sclerosis (PwMS) are suggested to have a higher death rate compared to the overall population. Increased risk and incidence of cardiovascular diseases is a possible contributing factor here, as these patients are suggested to be more prone to early death due to myocardial infarction (MI). AIM: This systematic review aims to describe the prevalence of MI among PwMS in comparison to the non-MS population. METHOD: We thoroughly searched for publications reporting the prevalence of MI among PwMS in PubMed, Scopus, Embase, and Web of Science. We excluded studies focusing on the following conditions: ischemic heart disease only, autopsy of PwMS, MS patients with a previous history of cardiovascular diseases, and MS diagnosed after MI. Moreover, we excluded reviews, editorials, and commentaries. We used the random effect model to calculate the pooled prevalence. RESULTS: We included nineteen studies, comprising 44 to 66616 participants. The overall prevalence of MI was 1.7% among PwMS. The pooled odds ratio estimate for MI was 1.41 in PwMS compared to the MS-free population. CONCLUSIONS: Results of this systematic review confirms the increased risk of MI among PwMS. Consequently, cardiovascular diseases should be considered in the management of these patients.