Literature DB >> 34633858

Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis.

Huajun Han1,2, Stephen Safe2,3, Arul Jayaraman4, Robert S Chapkin1,2.   

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. The AhR is an ancient conserved protein and is widely expressed across different tissues in vertebrates and invertebrates. AhR signaling mediates a wide range of cellular functions in a ligand-, cell type-, species-, and context-specific manner. Dysregulation of AhR signaling is linked to many developmental defects and chronic diseases. In this review, we discuss the emerging role of AhR signaling in mediating bidirectional host-microbiome interactions. We also consider evidence showing the potential for the dietary/microbial enhancement ofhealth-promoting AhR ligands to improve clinical pathway management in the context of inflammatory bowel diseases and colon tumorigenesis.

Entities:  

Keywords:  aryl hydrocarbon receptor; colon cancer; gut microbiota; inflammatory bowel disease; ligands

Mesh：

Substances：

Year:  2021        PMID： 34633858      PMCID： PMC8667662          DOI： 10.1146/annurev-nutr-043020-090050

Source DB:  PubMed          Journal:  Annu Rev Nutr        ISSN： 0199-9885            Impact factor:   11.848


  155 in total

1.  Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.

Authors:  A McDougal; M Wormke; J Calvin; S Safe
Journal:  Cancer Res       Date:  2001-05-15       Impact factor: 12.701

Review 2.  The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases.

Authors:  Helena Tlaskalová-Hogenová; Renata Stěpánková; Hana Kozáková; Tomáš Hudcovic; Luca Vannucci; Ludmila Tučková; Pavel Rossmann; Tomáš Hrnčíř; Miloslav Kverka; Zuzana Zákostelská; Klára Klimešová; Jaroslava Přibylová; Jiřina Bártová; Daniel Sanchez; Petra Fundová; Dana Borovská; Dagmar Srůtková; Zdeněk Zídek; Martin Schwarzer; Pavel Drastich; David P Funda
Journal:  Cell Mol Immunol       Date:  2011-01-31       Impact factor: 11.530

3.  TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome.

Authors:  Robert D Stedtfeld; Tiffany M Stedtfeld; Kelly A Fader; Maggie R Williams; Prianca Bhaduri; John Quensen; Timothy R Zacharewski; James M Tiedje; Syed A Hashsham
Journal:  FEMS Microbiol Ecol       Date:  2017-05-01       Impact factor: 4.194

4.  Aryl Hydrocarbon Receptor (AhR) Ligands as Selective AhR Modulators: Genomic Studies.

Authors:  Stephen Safe; Huajun Han; Jennifer Goldsby; Kumaravel Mohankumar; Robert S Chapkin
Journal:  Curr Opin Toxicol       Date:  2018-11-22

5.  The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor.

Authors:  Jennifer C Schroeder; Brett C Dinatale; Iain A Murray; Colin A Flaveny; Qiang Liu; Elizabeth M Laurenzana; Jyh Ming Lin; Stephen C Strom; Curtis J Omiecinski; Shantu Amin; Gary H Perdew
Journal:  Biochemistry       Date:  2010-01-19       Impact factor: 3.162

Review 6.  Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.

Authors:  Allison Agus; Julien Planchais; Harry Sokol
Journal:  Cell Host Microbe       Date:  2018-06-13       Impact factor: 21.023

7.  Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self-renewal of colonic stem and progenitor cells.

Authors:  Huajun Han; Laurie A Davidson; Yang-Yi Fan; Jennifer S Goldsby; Grace Yoon; Un-Ho Jin; Gus A Wright; Kerstin K Landrock; Bradley R Weeks; Rachel C Wright; Clinton D Allred; Arul Jayaraman; Ivan Ivanov; Jatin Roper; Stephen H Safe; Robert S Chapkin
Journal:  EMBO J       Date:  2020-08-10       Impact factor: 11.598

8.  Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles.

Authors:  Troy D Hubbard; Iain A Murray; William H Bisson; Tejas S Lahoti; Krishne Gowda; Shantu G Amin; Andrew D Patterson; Gary H Perdew
Journal:  Sci Rep       Date:  2015-08-03       Impact factor: 4.379

9.  Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

Authors:  Margaret M Lowe; Jeff E Mold; Bittoo Kanwar; Yong Huang; Alexander Louie; Michael P Pollastri; Cuihua Wang; Gautam Patel; Diana G Franks; Jennifer Schlezinger; David H Sherr; Allen E Silverstone; Mark E Hahn; Joseph M McCune
Journal:  PLoS One       Date:  2014-02-03       Impact factor: 3.240

Review 10.  Bioavailability of Glucosinolates and Their Breakdown Products: Impact of Processing.

Authors:  Francisco J Barba; Nooshin Nikmaram; Shahin Roohinejad; Anissa Khelfa; Zhenzhou Zhu; Mohamed Koubaa
Journal:  Front Nutr       Date:  2016-08-16
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  3 in total

1.  Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon.

Authors:  Robert S Chapkin; Laurie A Davidson; Hyejin Park; Un-Ho Jin; Yang-Yi Fan; Yating Cheng; Martha E Hensel; Kerstin K Landrock; Clinton Allred; Rani Menon; Cory Klemashevich; Arul Jayaraman; Stephen Safe
Journal:  Mol Nutr Food Res       Date:  2021-08-31       Impact factor: 6.575

Review 2.  Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases.

Authors:  Alkeiver S Cannon; Prakash S Nagarkatti; Mitzi Nagarkatti
Journal:  Int J Mol Sci       Date:  2021-12-28       Impact factor: 5.923

3.  Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults.

Authors:  Niknaz Riazati; Mary E Kable; John W Newman; Yuriko Adkins; Tammy Freytag; Xiaowen Jiang; Charles B Stephensen
Journal:  Front Immunol       Date:  2022-09-29       Impact factor: 8.786
  3 in total

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