| Literature DB >> 34633502 |
Nikolas Ruffer1, Nicola M Tomas2, Stefan Schmiedel3, Sabine Jordan3,4, Ina Kötter5,2.
Abstract
Visceral leishmaniasis (VL) is a chronic parasitic disease caused by pathogens of the genus Leishmania, which can mimic numerous diseases. The leading symptoms of VL (splenomegaly, pancytopenia, fever) can be misinterpreted, especially if autoantibodies are detected, and lead to the misdiagnosis of an underlying rheumatic disease (e.g. systemic lupus erythematosus, Felty's syndrome). Proinflammatory cytokines such as tumour necrosis factor alpha (TNF-α) play an important role in infection control. In this context, there are increasing reports of VL as an opportunistic infection during treatment with anti-TNF‑α agents. A case of VL mimicking Felty's syndrome in a patient with rheumatoid arthritis treated with methotrexate and etanercept is presented.Entities:
Keywords: Anti-TNF-α agent; Leishmania infantum; Opportunistic infection; Pancytopenia; Tumour necrosis factor alpha
Mesh:
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Year: 2021 PMID: 34633502 DOI: 10.1007/s00393-021-01105-0
Source DB: PubMed Journal: Z Rheumatol ISSN: 0340-1855 Impact factor: 1.372