Literature DB >> 34633502

[Visceral leishmaniasis mimicking Felty's syndrome in rheumatoid arthritis treated with methotrexate and etanercept].

Nikolas Ruffer1, Nicola M Tomas2, Stefan Schmiedel3, Sabine Jordan3,4, Ina Kötter5,2.   

Abstract

Visceral leishmaniasis (VL) is a chronic parasitic disease caused by pathogens of the genus Leishmania, which can mimic numerous diseases. The leading symptoms of VL (splenomegaly, pancytopenia, fever) can be misinterpreted, especially if autoantibodies are detected, and lead to the misdiagnosis of an underlying rheumatic disease (e.g. systemic lupus erythematosus, Felty's syndrome). Proinflammatory cytokines such as tumour necrosis factor alpha (TNF-α) play an important role in infection control. In this context, there are increasing reports of VL as an opportunistic infection during treatment with anti-TNF‑α agents. A case of VL mimicking Felty's syndrome in a patient with rheumatoid arthritis treated with methotrexate and etanercept is presented.
© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Entities:  

Keywords:  Anti-TNF-α agent; Leishmania infantum; Opportunistic infection; Pancytopenia; Tumour necrosis factor alpha

Mesh:

Substances:

Year:  2021        PMID: 34633502     DOI: 10.1007/s00393-021-01105-0

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN: 0340-1855            Impact factor:   1.372


  8 in total

Review 1.  Leishmaniasis in immunosuppressed individuals.

Authors:  J van Griensven; E Carrillo; R López-Vélez; L Lynen; J Moreno
Journal:  Clin Microbiol Infect       Date:  2014-02-20       Impact factor: 8.067

2.  Does ocular inflammation play a role in xeroderma pigmentosum with endothelial dysfunction: an immunological study.

Authors:  Amreen Aslam; Noopur Gupta; Thirumurthy Velpandian; Seema Sen
Journal:  BMJ Case Rep       Date:  2018-11-28

3.  Tumor necrosis factor alpha antagonist drugs and leishmaniasis in Europe.

Authors:  P Zanger; I Kötter; P G Kremsner; S Gabrysch
Journal:  Clin Microbiol Infect       Date:  2011-10-10       Impact factor: 8.067

4.  Focal spleen lesions in visceral leishmaniasis, a neglected manifestation of a neglected disease: report of three cases and systematic review of literature.

Authors:  Francesca Rinaldi; Susanna Giachè; Michele Spinicci; Paola Corsi; Silvia Ambu; Giacomo Gianfaldoni; Luigi Rigacci; Umberto Arena; Alessandro Bartoloni; Lorenzo Zammarchi
Journal:  Infection       Date:  2019-02-15       Impact factor: 3.553

Review 5.  Felty's syndrome without rheumatoid arthritis?

Authors:  Ap Rozin; R Hoffman; T Hayek; A Balbir-Gurman
Journal:  Clin Rheumatol       Date:  2013-01-05       Impact factor: 2.980

Review 6.  Leishmaniasis in rheumatology, haematology and oncology: epidemiological, immunological and clinical aspects and caveats.

Authors:  Christian Bogdan
Journal:  Ann Rheum Dis       Date:  2012-04       Impact factor: 19.103

Review 7.  Visceral leishmaniasis mimicking systemic lupus erythematosus: Case series and a systematic literature review.

Authors:  Iuri Usêda Santana; Blenda Dias; Eduardo Araújo Santana Nunes; Francisco Airton Castro da Rocha; Francisco Saraiva Silva; Mittermayer Barreto Santiago
Journal:  Semin Arthritis Rheum       Date:  2014-12-29       Impact factor: 5.532

8.  Non-articular Felty's syndrome: An uncommon diagnosis.

Authors:  T Jain; C Mittal; R Sengupta; B Rubin
Journal:  Neth J Med       Date:  2015-11       Impact factor: 1.422

  8 in total

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