| Literature DB >> 34632765 |
Shengnan Lin1, Jianchao Cui1, Yu Chen1, Yi Li1.
Abstract
We reported herein a copper-catalyzed trifluoromethylarylated cycloaddition of imidazoles and olefins using CF3SO2Cl as the radical source to synthesize highly functionalized tricyclic imidazoles. This procedure exhibits a wide range of substrate scope with 25%-93% isolated yields (36 examples). Mechanistic studies were carried out to support a free trifluoromethyl radical pathway.Entities:
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Year: 2021 PMID： 34632765 DOI： 10.1021/acs.joc.1c01832
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354