| Literature DB >> 34631891 |
Lian Guan1,2, Xu Zhao1,2, Lin Tang1,2, Jing Chen1,2, Juanjuan Zhao1,2, Mengmeng Guo1,2, Chao Chen1,2, Ya Zhou3, Lin Xu1,2.
Abstract
Thyroid transcription factor-1 (TTF-1/NKx2.1) is a member of the NKx2 tissue-specific transcription factor family, which is expressed in thyroid follicle, parathyroid gland, alveolar epithelium, and diencephalon which originated from ectoderm, and participates in the differentiation, development, and functional maintenance of the above organs. Recent studies have shown that the abnormal expression of TTF-1 is closely related to the occurrence of a variety of human diseases and can be used as a potential new target for the diagnosis and treatment of related diseases. In this article, in order to strengthen the systematic understanding of TTF-1 and promote the progress of related research, we reviewed the structure, expression regulation, biological functions of TTF-1, and its role in the occurrence and development of human-related clinical diseases. Meanwhile, we prospect the future research direction of TTF-1, which might ultimately contribute to the understanding of the pathogenesis of related clinical diseases and the development of new prevention and treatment strategies.Entities:
Mesh：
Substances：
Year: 2021 PMID： 34631891 PMCID： PMC8494563 DOI： 10.1155/2021/9957209
Source DB: PubMed Journal: Biomed Res Int Impact factor: 3.411