Fei Gong1,2,3, Berthold Hocher4,5,6,7, Huijun Chen8, Jian Li9, Sufen Cai8,10, Suimin Zeng9, Chenjun Yin9, Weihong Kuang9, Kexin Cheng9, Yao Jiang9, Mingqiu Tao9, Chang Chu11,12, Johann-Georg Hocher12, Ge Lin8,10,13. 1. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. gongfei20181224@163.com. 2. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China. gongfei20181224@163.com. 3. Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China. gongfei20181224@163.com. 4. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. berthold.hocher@medma.uni-heidelberg.de. 5. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China. berthold.hocher@medma.uni-heidelberg.de. 6. Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany. berthold.hocher@medma.uni-heidelberg.de. 7. Institute of Medical Diagnostics, IMD, Berlin, Germany. berthold.hocher@medma.uni-heidelberg.de. 8. Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China. 9. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China. 10. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China. 11. Department of Nephrology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany. 12. Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany. 13. Key Laboratory of Stem Cells and Reproductive Engineering, Ministry of Health, Changsha, China.
Abstract
OBJECTIVE: To investigate the impact of body mass index (BMI) on the success rate and prenatal outcomes of fresh embryo transfer in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment. METHODS: It is a post-hoc analysis of a prospective observational cohort study. 2569 Chinese women were grouped in quintiles of BMI and according to the official Chinese classification of body weight. IVF/ICSI and pregnancy outcomes were compared between groups. RESULTS: BMI was not associated with IVF/ICSI pregnancy outcomes including hCG positive rate, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, ongoing pregnancy rate, early miscarriage rate, and live birth rate. However, it was negatively related to some pregnancy complications such as gestational diabetes mellitus (GDM) and hypertension. Additionally, the proportion of Cesarean-section was increased with BMI. As for prenatal outcomes, the current results showed no statistical difference in the number of male and female newborn, the proportion of low live birth weight (<2500 g), macrosomia (≥4000 g) (both in all live birth and full-term live birth), and premature delivery (<37 weeks). CONCLUSIONS: The current study showed that BMI was not associated with embryo transfer outcomes after fresh embryo transfer in women undergoing their first IVF/ICSI treatment, whereas BMI was associated with GDM and gestational hypertension.
OBJECTIVE: To investigate the impact of body mass index (BMI) on the success rate and prenatal outcomes of fresh embryo transfer in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment. METHODS: It is a post-hoc analysis of a prospective observational cohort study. 2569 Chinese women were grouped in quintiles of BMI and according to the official Chinese classification of body weight. IVF/ICSI and pregnancy outcomes were compared between groups. RESULTS: BMI was not associated with IVF/ICSI pregnancy outcomes including hCG positive rate, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, ongoing pregnancy rate, early miscarriage rate, and live birth rate. However, it was negatively related to some pregnancy complications such as gestational diabetes mellitus (GDM) and hypertension. Additionally, the proportion of Cesarean-section was increased with BMI. As for prenatal outcomes, the current results showed no statistical difference in the number of male and female newborn, the proportion of low live birth weight (<2500 g), macrosomia (≥4000 g) (both in all live birth and full-term live birth), and premature delivery (<37 weeks). CONCLUSIONS: The current study showed that BMI was not associated with embryo transfer outcomes after fresh embryo transfer in women undergoing their first IVF/ICSI treatment, whereas BMI was associated with GDM and gestational hypertension.