Ruina Zhang1, Alberto Moscona1, Khrystyna Myndzar1, Elliot Luttrell-Williams1, Sally Vanegas2, Melanie R Jay2, Karry Calderon1, Jeffrey S Berger3, Sean P Heffron4. 1. Department of Medicine, Leon H. Charney Division of Cardiology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA. 2. Department of Medicine, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA. 3. Department of Medicine, Leon H. Charney Division of Cardiology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA; NYU Center for the Prevention of Cardiovascular Disease, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA; Department of Surgery, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA. 4. Department of Medicine, Leon H. Charney Division of Cardiology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA; NYU Center for the Prevention of Cardiovascular Disease, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA. Electronic address: Heffron@nyulangone.org.
Abstract
BACKGROUND AND AIMS: Obesity is an independent risk factor for atherosclerotic cardiovascular disease (CVD), and platelet hyperactivation in obesity may contribute to this association. Olive oil consumption is associated with lower cardiovascular disease (CVD) risk in the general population. However, little is known for individuals with obesity. We investigated whether olive oil intake is associated with platelet activation in obesity. METHODS AND RESULTS: We assessed platelet activation (surface P-selectin expression) with and without thrombin exposure and diet composition in 63 patients with severe obesity. Among 63 subjects with obesity, the mean age was 32.2 ± 8.0 years and BMI 44.1 ± 8.5 kg/m2. Olive oil intake was stratified into <1 time/week (n = 21), 1-3 times/week (n = 18), ≥4 times/week (n = 24). Strata did not differ by age, BMI or platelet count. Unstimulated P-selectin expression did not differ by olive oil consumption. Subjects with more frequent olive oil intake exhibited lower P-selectin expression on submaximal thrombin exposure. CONCLUSIONS: More frequent olive oil intake is associated with reduced thrombin-induced platelet activation in obesity.
BACKGROUND AND AIMS: Obesity is an independent risk factor for atherosclerotic cardiovascular disease (CVD), and platelet hyperactivation in obesity may contribute to this association. Olive oil consumption is associated with lower cardiovascular disease (CVD) risk in the general population. However, little is known for individuals with obesity. We investigated whether olive oil intake is associated with platelet activation in obesity. METHODS AND RESULTS: We assessed platelet activation (surface P-selectin expression) with and without thrombin exposure and diet composition in 63 patients with severe obesity. Among 63 subjects with obesity, the mean age was 32.2 ± 8.0 years and BMI 44.1 ± 8.5 kg/m2. Olive oil intake was stratified into <1 time/week (n = 21), 1-3 times/week (n = 18), ≥4 times/week (n = 24). Strata did not differ by age, BMI or platelet count. Unstimulated P-selectin expression did not differ by olive oil consumption. Subjects with more frequent olive oil intake exhibited lower P-selectin expression on submaximal thrombin exposure. CONCLUSIONS: More frequent olive oil intake is associated with reduced thrombin-induced platelet activation in obesity.
Authors: Ravi V Shah; Shih-Jen Hwang; Ashish Yeri; Kahraman Tanriverdi; Alexander R Pico; Chen Yao; Venkatesh Murthy; Jennifer Ho; Olga Vitseva; Danielle Demarco; Sajani Shah; Mark D Iafrati; Daniel Levy; Jane E Freedman Journal: Arterioscler Thromb Vasc Biol Date: 2019-01 Impact factor: 8.311
Authors: Éva Csongrádi; Béla Nagy; Tibor Fulop; Zsuzsa Varga; Zsolt Karányi; Mária T Magyar; László Oláh; Mária Papp; Andrea Facskó; János Kappelmayer; György Paragh; Miklós Káplár Journal: Thromb Haemost Date: 2011-08-25 Impact factor: 5.249
Authors: Antoni Pastor; Jose Rodríguez-Morató; Eulàlia Olesti; Mitona Pujadas; Clara Pérez-Mañá; Olha Khymenets; Montserrat Fitó; María-Isabel Covas; Rosa Solá; María-José Motilva; Magí Farré; Rafael de la Torre Journal: J Chromatogr A Date: 2016-02-06 Impact factor: 4.759
Authors: F Visioli; M Franco; E Toledo; J Luchsinger; W C Willett; F B Hu; M A Martinez-Gonzalez Journal: Nutr Metab Cardiovasc Dis Date: 2018-04-26 Impact factor: 4.222
Authors: María N Barrachina; Aurelio M Sueiro; Irene Izquierdo; Lidia Hermida-Nogueira; Esteban Guitián; Felipe F Casanueva; Richard W Farndale; Masaaki Moroi; Stephanie M Jung; María Pardo; Ángel García Journal: Atherosclerosis Date: 2018-12-25 Impact factor: 5.162