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Literature DB >> 3462701

Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes.

Abstract

We have examined the interaction of factors in HeLa cell nuclear extracts with a human histone H2B gene (H2B) promoter. Protein-DNA mobility-shift and DNase I protection assays detected a factor(s) binding to a 15-base-pair consensus element that is essential for efficient H2B transcription in vitro. Part of this consensus sequence is the octanucleotide ATTTGCAT, which is apparently a functional component of several non-histone genes. A subset of these genes, including a human U2 small nuclear RNA (snRNA) gene promoter, a mouse immunoglobulin heavy chain enhancer, and a mouse light chain promoter, were shown to interact with the H2B consensus sequence-binding factor(s). These results suggest that a common factor or closely related factors may contribute to the regulation of these and other genes that share the octanucleotide sequence.

Entities: Chemical Gene Species

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Year: 1986 PMID： 3462701 PMCID： PMC386507 DOI： 10.1073/pnas.83.17.6382

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

1. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes.

Authors: H Singh; R Sen; D Baltimore; P A Sharp
Journal: Nature Date: 1986 Jan 9-15 Impact factor: 49.962

2. The primary structure and expression of four cloned human histone genes.

Authors: R Zhong; R G Roeder; N Heintz
Journal: Nucleic Acids Res Date: 1983-11-11 Impact factor: 16.971

3. Two regulatory elements for immunoglobulin kappa light chain gene expression.

Authors: Y Bergman; D Rice; R Grosschedl; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1984-11 Impact factor: 11.205

4. B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo.

Authors: A Ephrussi; G M Church; S Tonegawa; W Gilbert
Journal: Science Date: 1985-01-11 Impact factor: 47.728

5. Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.

Authors: T G Parslow; D L Blair; W J Murphy; D K Granner
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

6. Structure of two unlinked Drosophila melanogaster glyceraldehyde-3-phosphate dehydrogenase genes.

Authors: J Y Tso; X H Sun; R Wu
Journal: J Biol Chem Date: 1985-07-05 Impact factor: 5.157

7. Orientation-dependent transcriptional activator upstream of a human U2 snRNA gene.

Authors: M Ares; M Mangin; A M Weiner
Journal: Mol Cell Biol Date: 1985-07 Impact factor: 4.272

8. Genomic organization and nucleotide sequence of two distinct histone gene clusters from Xenopus laevis. Identification of novel conserved upstream sequence elements.

Authors: M Perry; G H Thomsen; R G Roeder
Journal: J Mol Biol Date: 1985-10-05 Impact factor: 5.469

9. A general upstream binding factor for genes of the yeast translational apparatus.

Authors: J Huet; P Cottrelle; M Cool; M L Vignais; D Thiele; C Marck; J M Buhler; A Sentenac; P Fromageot
Journal: EMBO J Date: 1985-12-16 Impact factor: 11.598

10. Human U2 and U1 RNA genes use similar transcription signals.

Authors: G Westin; E Lund; J T Murphy; U Pettersson; J E Dahlberg
Journal: EMBO J Date: 1984-12-20 Impact factor: 11.598

100 in total

1. Combination of a zinc finger and homeodomain required for protein-interaction.

Authors: Gregory E Smith; Douglas S Darling
Journal: Mol Biol Rep Date: 2003-12 Impact factor: 2.316

2. B cell development and immunoglobulin transcription in Oct-1-deficient mice.

Authors: Victoria E H Wang; Dean Tantin; Jianzhu Chen; Phillip A Sharp
Journal: Proc Natl Acad Sci U S A Date: 2004-02-04 Impact factor: 11.205

3. A constitutive enhancer in the bovine papillomavirus upstream regulatory region shares genetic elements with the viral P1 promoter.

Authors: G L Bream; P Vaillancourt; M R Botchan
Journal: J Virol Date: 1992-12 Impact factor: 5.103

4. The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity.

Authors: C L Dent; K A Lillycrop; J K Estridge; N S Thomas; D S Latchman
Journal: Mol Cell Biol Date: 1991-08 Impact factor: 4.272

5. Xenopus laevis Oct-1 does not bind to certain histone H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity.

Authors: D P Smith; R W Old
Journal: Nucleic Acids Res Date: 1991-02-25 Impact factor: 16.971

6. Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration.

Authors: I Kemler; E Bucher; K Seipel; M M Müller-Immerglück; W Schaffner
Journal: Nucleic Acids Res Date: 1991-01-25 Impact factor: 16.971

7. Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.

Authors: T A Libermann; M Lenardo; D Baltimore
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

8. Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function.

Authors: B Nelsen; T Kadesch; R Sen
Journal: Mol Cell Biol Date: 1990-06 Impact factor: 4.272

9. X-box-binding proteins positively and negatively regulate transcription of the HLA-DRA gene through interaction with discrete upstream W and V elements.

Authors: J P Cogswell; P V Basta; J P Ting
Journal: Proc Natl Acad Sci U S A Date: 1990-10 Impact factor: 11.205

10. A distinct octamer-binding protein present in malignant melanoma cells.

Authors: P M Cox; S M Temperley; H Kumar; C R Goding
Journal: Nucleic Acids Res Date: 1988-12-09 Impact factor: 16.971