| Literature DB >> 34626720 |
Kazuyuki Aihara1, Rui Liu2, Keiichi Koizumi3, Xiaoping Liu4, Luonan Chen5.
Abstract
This paper reviews theory of DNB (Dynamical Network Biomarkers) and its applications including both modern medicine and traditional medicine. We show that omics data such as gene/protein expression profiles can be effectively used to detect pre-disease states before critical transitions from healthy states to disease states by using the DNB theory. The DNB theory with big biological data is expected to lead to ultra-early precision and preventive medicine.Entities:
Keywords: Bifurcation; Disease state; Dynamical network biomarker; Early warning signals; Healthy state; Pre-disease state; Tipping point; Ultra-early medicine
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Year: 2021 PMID： 34626720 DOI： 10.1016/j.gene.2021.145997
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688