Vito Romano1, Mohit Parekh2, Gianni Virgili3, Giulia Coco4, Pia Leon5, Katja Islein6, Diego Ponzin7, Stefano Ferrari7, Adriano Fasolo8, Angeli Christy Yu9, Ersilia Lucenteforte10, Massimo Busin9, Stephen B Kaye11. 1. From the Royal Liverpool University Hospital, Liverpool, UK (V.R, G.C, K.I, S.B.K); Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK (V.R, S.B.K). Electronic address: vito.romano@gmail.com. 2. UCL Institute of Ophthalmology, London, UK (M.P). 3. Centre for Public Health, Queen's University Belfast, Belfast, UK (G.V); Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy (G.V). 4. From the Royal Liverpool University Hospital, Liverpool, UK (V.R, G.C, K.I, S.B.K); Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy (G.C). 5. Department of Ophthalmology, SS Giovanni e Paolo Hospital ULSS12, Venice, Italy (P.L). 6. From the Royal Liverpool University Hospital, Liverpool, UK (V.R, G.C, K.I, S.B.K). 7. International Center for Ocular Physiopathology, Fondazione Banca degli Occhi del Veneto Onlus, Venice, Italy (D.P, S.F, A.F). 8. International Center for Ocular Physiopathology, Fondazione Banca degli Occhi del Veneto Onlus, Venice, Italy (D.P, S.F, A.F); Ophthalmology Clinic, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy (A.F). 9. Ospedali Privati Forlì "Villa Igea", Department of Ophthalmology, Forlì, Italy (A.C.Y, M.B); University of Ferrara, Department of Translational Medicine, Ferrara, Italy (A.C.Y, M.B). 10. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy (E.L). 11. From the Royal Liverpool University Hospital, Liverpool, UK (V.R, G.C, K.I, S.B.K); Department of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK (V.R, S.B.K).
Abstract
PURPOSE: To investigate whether donor to recipient gender or H-Y mismatching was associated with graft rejection or failure following Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with Fuchs endothelial corneal dystrophy (FECD). DESIGN: Clinical cohort study. METHODS: This study used a multi-center registry including patients aged >18 years who had undergone their first DSAEK for FECD between January 2008 and March 2018. The impact of donor and recipient gender incompatibility (including H-Y mismatches) on corneal graft rejection and failure was evaluated using Kaplan-Meier curves and univariable and multivariable Cox models. RESULTS: Outcome data from 4341 eyes (3915 from the UK and 426 from Italy) were analyzed. Graft failure at 2-year follow-up occurred in 477 (11.0%) cases. Graft rejection at 2-year follow-up occurred in 175 cases (4.0%), 58 (1.3%) of whom developed graft failure. There was no significant effect of gender or H-Y mismatching on either rejection (P = .12, P = .06) or failure (P = .28, P = .14), respectively. CONCLUSIONS: In patients with FECD undergoing DSAEK, no significant influence of gender and or H-Y mismatch on graft rejection or failure was found.
PURPOSE: To investigate whether donor to recipient gender or H-Y mismatching was associated with graft rejection or failure following Descemet stripping automated endothelial keratoplasty (DSAEK) in patients with Fuchs endothelial corneal dystrophy (FECD). DESIGN: Clinical cohort study. METHODS: This study used a multi-center registry including patients aged >18 years who had undergone their first DSAEK for FECD between January 2008 and March 2018. The impact of donor and recipient gender incompatibility (including H-Y mismatches) on corneal graft rejection and failure was evaluated using Kaplan-Meier curves and univariable and multivariable Cox models. RESULTS: Outcome data from 4341 eyes (3915 from the UK and 426 from Italy) were analyzed. Graft failure at 2-year follow-up occurred in 477 (11.0%) cases. Graft rejection at 2-year follow-up occurred in 175 cases (4.0%), 58 (1.3%) of whom developed graft failure. There was no significant effect of gender or H-Y mismatching on either rejection (P = .12, P = .06) or failure (P = .28, P = .14), respectively. CONCLUSIONS: In patients with FECD undergoing DSAEK, no significant influence of gender and or H-Y mismatch on graft rejection or failure was found.
Authors: Sota Nishisako; Takefumi Yamaguchi; Masatoshi Hirayama; Kazunari Higa; Dai Aoki; Chiaki Sasaki; Hisashi Noma; Jun Shimazaki Journal: Front Med (Lausanne) Date: 2022-02-04