Literature DB >> 3462380

The effects of megadoses of ascorbic acid on PMN chemotaxis and experimental gingivitis.

R I Vogel, I B Lamster, S A Wechsler, B Macedo, L J Hartley, J A Macedo.   

Abstract

A double-blind study was undertaken to determine the effects of megadose ascorbic acid supplementation on plasma ascorbate levels, polymorphonuclear neutrophil (PMN) chemotaxis and clinical and biochemical determinations of inflammatory progression in individuals with a mean daily ascorbate intake level of approximately twice the recommended daily allowances. Results indicate that although the group receiving ascorbate supplementation demonstrated a significant increase in plasma levels of the vitamin as compared to a placebo group, no significant differences with respect to PMN chemotaxis or responses to experimental gingivitis were found between the groups.

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Year:  1986        PMID: 3462380     DOI: 10.1902/jop.1986.57.8.472

Source DB:  PubMed          Journal:  J Periodontol        ISSN: 0022-3492            Impact factor:   6.993


  4 in total

1.  Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton.

Authors:  William H Parker; Elizabeth Meredith Rhea; Zhi-Chao Qu; Morgan R Hecker; James M May
Journal:  Am J Physiol Cell Physiol       Date:  2016-09-07       Impact factor: 4.249

2.  The association of dietary vitamin C intake with periodontitis among Korean adults: Results from KNHANES Ⅳ.

Authors:  Jung-Hoo Lee; Myung-Seop Shin; Eun-Jeong Kim; Yoo-Been Ahn; Hyun-Duck Kim
Journal:  PLoS One       Date:  2017-05-10       Impact factor: 3.240

3.  Effect of Vitamin C as an Adjunct in Nonsurgical Periodontal Therapy in Uncontrolled Type 2 Diabetes Mellitus Patients.

Authors:  Piyapat Kunsongkeit; Nis Okuma; Supanee Rassameemasmaung; Pechngam Chaivanit
Journal:  Eur J Dent       Date:  2019-07-07

Review 4.  Efficacy of vitamin C supplementation as an adjunct in the non-surgical management of periodontitis: a systematic review.

Authors:  Hytham N Fageeh; Hammam I Fageeh; Ashwin Prabhu; Shilpa Bhandi; Shahrukh Khan; Shankargouda Patil
Journal:  Syst Rev       Date:  2021-01-04
  4 in total

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