| Literature DB >> 34622920 |
Stina Ek1, Anna C Meyer1, Margareta Hedström2,3, Karin Modig1.
Abstract
BACKGROUND: Hospital length of stay (LoS) is believed to be associated with higher mortality in hip fracture patients; however, previous research has shown conflicting results. We aimed to explore the association between LoS and 4-month mortality in different groups of hip fracture patients.Entities:
Keywords: Health care; Injury; National registers; Prognosis
Mesh:
Year: 2022 PMID: 34622920 PMCID: PMC9255691 DOI: 10.1093/gerona/glab302
Source DB: PubMed Journal: J Gerontol A Biol Sci Med Sci ISSN: 1079-5006 Impact factor: 6.591
Baseline Characteristics of the Study Population by LoS
| All ( | LoS 2–4 days ( | LoS 5–8 days ( | LoS 9–12 days ( | LoS 13–23 days ( | LoS 24+ days ( | |
|---|---|---|---|---|---|---|
| Age, mean ( | 83.0 (7.9) | 81.6 (8.8) | 82.4 (8.3) | 83.1 (7.6) | 83.9 (7.4) | 84.0 (7.3) |
| ASA score, | ||||||
| 1 | 2 257 (4.7) | 404 (7.9) | 793 (6.2) | 604 (4.5) | 414 (2.9) | 42 (2.0) |
| 2 | 18 079 (37.8) | 1 928 (37.7) | 5 010 (39.2) | 5 412 (40.7) | 5 076 (35.1) | 653 (30.3) |
| 3 | 24 567 (51.4) | 2 443 (47.8) | 6 272 (49.1) | 6 592 (49.6) | 8 004 (55.3) | 1 256 (58.3) |
| 4–5 | 2 908 (6.1) | 339 (6.6) | 688 (5.2) | 688 (5.2) | 976 (6.7) | 202 (9.4) |
| Walking ability before admission, | ||||||
| Independent | 28 951 (60.6) | 2 091 (40.9) | 6 735 (52.7) | 8 993 (67.6) | 9 718 (67.2) | 1 414 (65.7) |
| Assisted outside | 4 216 (8.8) | 553 (10.8) | 1 146 (9.0) | 1 021 (7.7) | 1 301 (9.0) | 195 (9.1) |
| Independent inside | 10 308 (21.6) | 1 559 (30.5) | 3 247 (25.4) | 2 422 (18.2) | 2 675 (18.5) | 405 (18.8) |
| Assisted inside | 3 100 (6.5) | 617 (12.1) | 1 204 (9.4) | 624 (4.7) | 553 (3.8) | 102 (4.7) |
| Not able to walk | 1 236 (2.6) | 294 (5.8) | 446 (3.5) | 236 (1.8) | 223 (1.5) | 37 (1.7) |
| Living arrangements before admission, | ||||||
| Own home | 34 290 (71.7) | 1 786 (34.9) | 6 960 (54.5) | 10 953 (82.4) | 12 695 (87.7) | 1 896 (88.1) |
| Care home or similar | 11 617 (24.3) | 3 149 (61.6) | 5 385 (42.1) | 1 856 (14.0) | 1 123 (7.8) | 104 (4.8) |
| Other health care facility | 1 904 (4.0) | 179 (3.5) | 433 (3.4) | 487 (3.7) | 652 (4.5) | 153 (7.1) |
| 4-month mortality, | 5 879 (12.3) | 939 (18.4) | 1 842 (14.4) | 1 313 (9.9) | 1 495 (10.3) | 290 (12.3) |
| Cause of death, | ||||||
| Infection | 128 (2.2) | 16 (1.7) | 33 (1.8) | 31 (2.4) | 37 (2.5) | 11 (3.8) |
| Tumors | 706 (12.0) | 66 (7.0) | 168 (9.1) | 188 (14.3) | 241 (16.1) | 43 (14.8) |
| Endocrine | 110 (1.9) | 21 (2.2) | 25 (1.4) | 30 (2.3) | 27 (1.8) | 7 (2.4) |
| Psychological including dementia | 811 (13.8) | 208 (22.2) | 343 (18.6) | 127 (9.7) | 112 (7.5) | 21 (7.2) |
| Neurological | 386 (6.6) | 107 (11.4) | 161 (8.7) | 56 (2.3) | 55 (3.7) | 7 (2.4) |
| Cardiovascular | 2 022 (34.4) | 257 (27.4) | 605 (32.8) | 475 (36.2) | 575 (38.5) | 110 (37.9) |
| Respiratory | 246 (4.2) | 10 (1.1) | 49 (2.7) | 67 (5.1) | 96 (6.4) | 24 (8.3) |
| Injuries and trauma | 1 005 (17.1) | 188 (20.0) | 343 (18.6) | 225 (17.1) | 215 (14.4) | 34 (11.7) |
| Other or UNS | 465 (7.9) | 66 (7.0) | 115 (6.2) | 114 (8.7) | 137 (9.2) | 33 (11.4) |
Note: LoS = length of hospital stay; SD = standard deviation; ASA = American Society of Anesthesiologists physical status classification; UNS = unspecified.
*Subsample of deceased within 4 months, n = 5 879.
Hazard Ratios for the Association Between LoS and 4-Month Mortality
| Hazard Ratios, 95% CI | |||||||
|---|---|---|---|---|---|---|---|
| n | Cases | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
| LoS, in days | |||||||
| 2–4 | 5 114 | 939 |
|
|
| 1.04 (0.96–1.14) | 1.06 (0.97–1.16) |
| 5–8 | 12 778 | 1 842 |
|
|
| 0.98 (0.91–1.15) | 0.99 (0.92–1.07) |
| 9–12 | 13 296 | 1 313 | Ref. | Ref. | Ref. | Ref. | Ref. |
| 13–23 | 14 470 | 1 495 | 0.98 (0.91–1.05) | 0.93 (0.86–0.99) | 1.01 (0.94–1.09) |
|
|
| 24+ | 2 153 | 290 |
|
|
|
|
|
| ASA score | |||||||
| 1 | Ref. | Ref. | |||||
| 2 | — |
| — | — |
| ||
| 3 | — |
| — | — |
| ||
| 4–5 | — |
| — | — |
| ||
| Walking ability | |||||||
| Independent | Ref. | Ref. | |||||
| Assisted outside | — | — |
| — |
| ||
| Independently inside | — | — |
| — |
| ||
| Assisted inside | — | — |
| — |
| ||
| Not able to walk | — | — |
| — |
| ||
| Living arrangement before admission | |||||||
| Own living | Ref. | Ref. | |||||
| Any service accommodation | — | — | — |
|
| ||
| Other health care instance | — | — | — |
|
| ||
Notes: LoS = length of hospital stay; CI = confidence interval; ASA = American Society of Anesthesiologists physical status classification. Model 1: adjusted for age and sex; Model 2: adjusted for age, sex, and ASA score; Model 3: adjusted age, sex, and walking ability before the fracture; Model 4: adjusted for age, sex, and living arrangements before admission; Model 5: adjusted for all factors above. Statistically significant hazard ratios are denoted in bold.
Figure 1.Hazard ratios for the association between days of LoS and 4-month mortality with 11 days as reference: (A) unadjusted model and (B) fully adjusted model (sex, age, ASA grade, walking ability, and living arrangements). LoS = length of hospital stay; ASA = American Society of Anesthesiologists physical status classification.
Hazard Ratios for the Association Between LoS and 4-Month Mortality, Stratified by Type of Living Arrangement Before Admission
| Hazard Ratios, 95% CI | |||||||
|---|---|---|---|---|---|---|---|
| n | Cases | Absolute Risk, % | Model 1 | Model 2 | Model 3 | Model 4 | |
| Own home ( | |||||||
| LoS, in days | |||||||
| 2–4 | 1 786 | 37 | 2.1 |
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|
|
|
| 5–8 | 6 960 | 289 | 4.2 |
|
|
|
|
| 9–12 | 10 953 | 729 | 6.7 | Ref. | Ref. | Ref. | Ref. |
| 13–23 | 12 695 | 1 084 | 8.5 |
| 1.08 (0.99–1.19) |
| 1.07 (0.97–1.18) |
| 24+ | 1 896 | 224 | 11.8 |
|
|
|
|
| Health care facility or care home ( | |||||||
| LoS, in days | |||||||
| 2–4 | 3 328 | 902 | 27.1 |
|
|
|
|
| 5–8 | 5 818 | 1 553 | 26.7 | 1.10 (0.99–1.21) |
| 1.08 (0.97–1.18) | 1.09 (0.99–1.19) |
| 9–12 | 2 343 | 584 | 24.9 | Ref. | Ref. | Ref. | Ref. |
| 13–23 | 1 775 | 411 | 23.2 | 0.95 (0.83–1.08) | 0.92 (0.83–1.05) | 0.99 (0.87–1.12) | 0.96 (0.85–1.09) |
| 24+ | 257 | 66 | 25.7 | 1.11 (0.86–1.43) | 1.07 (0.83–1.38) | 1.19 (0.92–1.53) | 1.14 (0.89–1.48) |
Notes: LoS = length of hospital stay; CI = confidence interval; ASA = American Society of Anesthesiologists physical status classification. Model 1: adjusted for age and sex; Model 2: adjusted for sex and ASA score; Model 3: adjusted for sex and walking ability before the fracture; Model 4: adjusted for all factors above. Statistically significant hazard ratios are denoted in bold.
Figure 2.Hazard ratios for the association between days of LoS and 4-month mortality with 11 days as reference, stratified on living arrangements: (A) unadjusted model and (B) fully adjusted model (sex, age, ASA grade, and walking ability). LoS = length of hospital stay; ASA = American Society of Anesthesiologists physical status classification.