Sumaiyah Mat1,2,3, Maw Pin Tan4,5,6, Mas Sahidayana Mohktar5,7, Shahrul Bahyah Kamaruzzaman6, Fatimah Ibrahim8,9,10. 1. Centre for Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia. sumaiyah.mat@ukm.edu.my. 2. Center for Innovation in Medical Engineering (CIME), Faculty of Engineering, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. sumaiyah.mat@ukm.edu.my. 3. Ageing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. sumaiyah.mat@ukm.edu.my. 4. Center for Innovation in Medical Engineering (CIME), Faculty of Engineering, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. 5. Ageing and Age-Associated Disorders Research Group, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. 6. Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. 7. Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. 8. Center for Innovation in Medical Engineering (CIME), Faculty of Engineering, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. fatimah@um.edu.my. 9. Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. fatimah@um.edu.my. 10. Centre for Printable Electronics, Universiti Malaya, 50603, Kuala Lumpur, Malaysia. fatimah@um.edu.my.
Abstract
OBJECTIVE: To evaluate the role of PhA in diabetes in a large population of older adults with a high prevalence of diabetes in order to gain new insights on the potential diagnostic and prognostic role of PhA in individuals with diabetes. DESIGN: Cross-sectional study. SETTING: Teaching Hospital. PARTICIPANTS: 1085 individuals aged 55 years or over. MEASUREMENTS: Phase Angle was obtained using bioimpedance analysis with the Bodystat QuadScan® 4000. Diabetes mellitus was considered present with fasting hyperglycaemia (serum fasting glucose >6.66 mmol/l), HbA1c > 42 mmol/mol (6.1%), or self-reported Diabetes or the consumption of glucose-lowering agents. RESULTS: The mean age of the (standard deviation) of the 1,085 participants was 68.11 (7.12) years and 60.7% were women. Among male participants, individuals with PhA within the lowest quartile (PhA ≤4.9) were significantly more likely to have diabetes mellitus [odds Ratio (95% confidence interval, CI), 2.02 (1.17-3.47)] following adjustments for age, body mass index and other comorbidities. The above relationship was attenuated following further adjustment hypoglycaemic medications. Men on oral hypoglycaemic agents had significantly reduced PhA [mean difference (95% CI), -0.44 (-0.67 to -0.22)]. No significant relationship between PhA and diabetes existed among women. CONCLUSION: The association between lower PhA (≤4.9) in men aged 55 and over and diabetes which is accounted for by oral hypoglycaemic agents. The mechanisms underlying this relationship remain unclear. This relationship should also be evaluated further to determine the potential of PhA as a prognostic tool for diabetes.
OBJECTIVE: To evaluate the role of PhA in diabetes in a large population of older adults with a high prevalence of diabetes in order to gain new insights on the potential diagnostic and prognostic role of PhA in individuals with diabetes. DESIGN: Cross-sectional study. SETTING: Teaching Hospital. PARTICIPANTS: 1085 individuals aged 55 years or over. MEASUREMENTS: Phase Angle was obtained using bioimpedance analysis with the Bodystat QuadScan® 4000. Diabetes mellitus was considered present with fasting hyperglycaemia (serum fasting glucose >6.66 mmol/l), HbA1c > 42 mmol/mol (6.1%), or self-reported Diabetes or the consumption of glucose-lowering agents. RESULTS: The mean age of the (standard deviation) of the 1,085 participants was 68.11 (7.12) years and 60.7% were women. Among male participants, individuals with PhA within the lowest quartile (PhA ≤4.9) were significantly more likely to have diabetes mellitus [odds Ratio (95% confidence interval, CI), 2.02 (1.17-3.47)] following adjustments for age, body mass index and other comorbidities. The above relationship was attenuated following further adjustment hypoglycaemic medications. Men on oral hypoglycaemic agents had significantly reduced PhA [mean difference (95% CI), -0.44 (-0.67 to -0.22)]. No significant relationship between PhA and diabetes existed among women. CONCLUSION: The association between lower PhA (≤4.9) in men aged 55 and over and diabetes which is accounted for by oral hypoglycaemic agents. The mechanisms underlying this relationship remain unclear. This relationship should also be evaluated further to determine the potential of PhA as a prognostic tool for diabetes.
Authors: Seok Won Park; Bret H Goodpaster; Elsa S Strotmeyer; Lewis H Kuller; Robert Broudeau; Candace Kammerer; Nathalie de Rekeneire; Tamara B Harris; Ann V Schwartz; Frances A Tylavsky; Yong-wook Cho; Anne B Newman Journal: Diabetes Care Date: 2007-03-15 Impact factor: 19.112
Authors: W M Wan Nazaimoon; S H Md Isa; W B Wan Mohamad; A S Khir; N A Kamaruddin; I M Kamarul; N Mustafa; I S Ismail; O Ali; B A K Khalid Journal: Diabet Med Date: 2013-03-23 Impact factor: 4.359