Literature DB >> 3461787

Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-beta.

J Varga, S A Jimenez.   

Abstract

Transforming growth factor-beta (TGF beta) a growth factor with diverse effects on cellular growth and metabolism, caused dramatic stimulation of total protein and collagen synthesis by confluent normal human dermal fibroblasts in culture in a dose-dependent manner. Gel electrophoresis of the newly synthesized macromolecules from the culture media of TGF beta treated cultures demonstrated accelerated procollagen processing. These results indicate that TGF beta is capable of qualitatively and quantitatively influencing the biosynthesis of matrix molecules by fibroblasts, and raise the possibility that TGF may play a role in the development of normal and pathologic fibrogenesis.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3461787     DOI： 10.1016/s0006-291x(86)80591-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  37 in total

1.  Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.

Authors:  Felix Chua; Sarah E Dunsmore; Peter H Clingen; Steven E Mutsaers; Steven D Shapiro; Anthony W Segal; Jürgen Roes; Geoffrey J Laurent
Journal:  Am J Pathol       Date:  2007-01       Impact factor: 4.307

2.  The Scar-in-a-Jar: studying potential antifibrotic compounds from the epigenetic to extracellular level in a single well.

Authors:  C Z C Chen; Y X Peng; Z B Wang; P V Fish; J L Kaar; R R Koepsel; A J Russell; R R Lareu; M Raghunath
Journal:  Br J Pharmacol       Date:  2009-09-28       Impact factor: 8.739

Review 3.  Pathogenesis of Systemic Sclerosis.

Authors:  Debendra Pattanaik; Monica Brown; Bradley C Postlethwaite; Arnold E Postlethwaite
Journal:  Front Immunol       Date:  2015-06-08       Impact factor: 7.561

4.  Identification of target proteins involved in cochlear otosclerosis.

Authors:  Céline Richard; Joni K Doherty; Jose N Fayad; Ana Cordero; Fred H Linthicum
Journal:  Otol Neurotol       Date:  2015-06       Impact factor: 2.311

5.  Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1 beta production by synovial T cells.

Authors:  E Robinson; E C Keystone; T J Schall; N Gillett; E N Fish
Journal:  Clin Exp Immunol       Date:  1995-09       Impact factor: 4.330

6.  Stimulation of alpha 1 (I) procollagen gene expression in NIH-3T3 cells by the human T cell leukemia virus type 1 (HTLV-1) Tax gene.

Authors:  E Muñoz; D Suri; S Amini; K Khalili; S A Jiménez
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808

7.  Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model.

Authors:  Juyoung Kim; Youngae Kim; Hyejeong Yun; Hyemin Park; Sun Yeou Kim; Kwang-Gill Lee; Sang-Mi Han; Yunhi Cho
Journal:  Nutr Res Pract       Date:  2010-10-26       Impact factor: 1.926

8.  Neuroaxonal dystrophy in HTLV-1-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations.

Authors:  E Wu; D W Dickson; S Jacobson; C S Raine
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

9.  Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

Authors:  R Raghow; A E Postlethwaite; J Keski-Oja; H L Moses; A H Kang
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

Review 10.  Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis.

Authors:  Jeffrey A Jones; Francis G Spinale; John S Ikonomidis
Journal:  J Vasc Res       Date:  2008-09-02       Impact factor: 1.934
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.