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Literature DB >> 34616879

The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential.

Aleix Bayona-Feliu^1,2, Andrés Aguilera^1,2.

Abstract

Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding.

Entities: Chemical

Keywords: Cancer; R-loops; SWI/SNF; cBAF; chromatin; epigenetics; genome instability; transcription-replication conflicts

Year: 2021 PMID： 34616879 PMCID： PMC8489945 DOI： 10.1080/23723556.2021.1976582

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

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Journal: EMBO J Date: 1998-01-02 Impact factor: 11.598

Review 2. R-Loops as Cellular Regulators and Genomic Threats.

Authors: Madzia P Crossley; Michael Bocek; Karlene A Cimprich
Journal: Mol Cell Date: 2019-02-07 Impact factor: 17.970

3. Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability.

Authors: Urszula L McClurg; Rossitsa Hristova; Lisa Prendergast; Rolando Berlinguer-Palmini; Sarah Greener; Katie Veitch; Inmaculada Hernandez; Philippe Pasero; Daniel Rico; Jonathan M G Higgins; Anastas Gospodinov; Manolis Papamichos-Chronakis
Journal: Nat Commun Date: 2020-09-10 Impact factor: 14.919

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Authors: J C Reyes; J Barra; C Muchardt; A Camus; C Babinet; M Yaniv
Journal: EMBO J Date: 1998-12-01 Impact factor: 11.598

5. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

Authors: Cigall Kadoch; Diana C Hargreaves; Courtney Hodges; Laura Elias; Lena Ho; Jeff Ranish; Gerald R Crabtree
Journal: Nat Genet Date: 2013-05-05 Impact factor: 38.330

Review 6. A compendium of mutational cancer driver genes.

Authors: Francisco Martínez-Jiménez; Ferran Muiños; Inés Sentís; Jordi Deu-Pons; Iker Reyes-Salazar; Claudia Arnedo-Pac; Loris Mularoni; Oriol Pich; Jose Bonet; Hanna Kranas; Abel Gonzalez-Perez; Nuria Lopez-Bigas
Journal: Nat Rev Cancer Date: 2020-08-10 Impact factor: 60.716

7. PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer.

Authors: Roman M Chabanon; Daphné Morel; Thomas Eychenne; Léo Colmet-Daage; Ilirjana Bajrami; Nicolas Dorvault; Marlène Garrido; Cornelia Meisenberg; Andrew Lamb; Carine Ngo; Suzanna R Hopkins; Theodoros I Roumeliotis; Samuel Jouny; Clémence Hénon; Asuka Kawai-Kawachi; Clémence Astier; Asha Konde; Elaine Del Nery; Christophe Massard; Stephen J Pettitt; Raphaël Margueron; Jyoti S Choudhary; Geneviève Almouzni; Jean-Charles Soria; Eric Deutsch; Jessica A Downs; Christopher J Lord; Sophie Postel-Vinay
Journal: Cancer Res Date: 2021-06-01 Impact factor: 12.701

1 in total

1. Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas.

Authors: Melanie Haas Kucherlapati
Journal: Cell Cycle Date: 2022-04-19 Impact factor: 5.173