Literature DB >> 34616878

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.

Pierre Raia1, Jun Yu1, Andreas Boland1.   

Abstract

Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids. We recently reported structures of human separase bound to its inhibitors securin or the cyclin-dependent kinase 1 (CDK1)-cyclin B1 (CCNB1)-cyclin-dependent kinases regulatory subunit 1 (CKS1) complex and discovered an array of molecular mechanisms that block cohesin-cleavage.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Cell cycle; autoinhibition; caspase; cohesin; mitosis; oncogene; substrate occlusion

Year:  2021        PMID： 34616878      PMCID： PMC8489941          DOI： 10.1080/23723556.2021.1975473

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast.

Authors:  F Uhlmann; D Wernic; M A Poupart; E V Koonin; K Nasmyth
Journal:  Cell       Date:  2000-10-27       Impact factor: 41.582

2.  Cohesin cleavage by separase required for anaphase and cytokinesis in human cells.

Authors:  S Hauf; I C Waizenegger; J M Peters
Journal:  Science       Date:  2001-08-17       Impact factor: 47.728

3.  Dual inhibition of sister chromatid separation at metaphase.

Authors:  O Stemmann; H Zou; S A Gerber; S P Gygi; M W Kirschner
Journal:  Cell       Date:  2001-12-14       Impact factor: 41.582

4.  Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.

Authors:  Susanne Hellmuth; Laura Gómez-H; Alberto M Pendás; Olaf Stemmann
Journal:  Nature       Date:  2020-04-08       Impact factor: 49.962

5.  An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.

Authors:  R Ciosk; W Zachariae; C Michaelis; A Shevchenko; M Mann; K Nasmyth
Journal:  Cell       Date:  1998-06-12       Impact factor: 41.582

6.  Molecular mechanism for the regulation of yeast separase by securin.

Authors:  Shukun Luo; Liang Tong
Journal:  Nature       Date:  2017-02-01       Impact factor: 49.962

7.  Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.

Authors:  Andreas Boland; Thomas G Martin; Ziguo Zhang; Jing Yang; Xiao-Chen Bai; Leifu Chang; Sjors H W Scheres; David Barford
Journal:  Nat Struct Mol Biol       Date:  2017-03-06       Impact factor: 15.369

8.  Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site.

Authors:  Laura E Rosen; Joseph E Klebba; Jonathan B Asfaha; Chloe M Ghent; Melody G Campbell; Yifan Cheng; David O Morgan
Journal:  Nat Commun       Date:  2019-11-15       Impact factor: 14.919

9.  Structural basis of human separase regulation by securin and CDK1-cyclin B1.

Authors:  Pierre Raia; Chloe M Ghent; Tobias Raisch; Jun Yu; Yashar Sadian; Simone Cavadini; Pramod M Sabale; David Barford; Stefan Raunser; David O Morgan; Andreas Boland
Journal:  Nature       Date:  2021-07-21       Impact factor: 49.962

10.  Structural basis of cohesin cleavage by separase.

Authors:  Zhonghui Lin; Xuelian Luo; Hongtao Yu
Journal:  Nature       Date:  2016-03-30       Impact factor: 49.962
  10 in total
  1 in total

1.  Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy.

Authors:  Martina Barbiero; Luca Cirillo; Sapthaswaran Veerapathiran; Catherine Coates; Camilla Ruffilli; Jonathon Pines
Journal:  Open Biol       Date:  2022-06-29       Impact factor: 7.124
  1 in total

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