Literature DB >> 34616871

Complex interplay between p53 and chromosome stability.

Akshay Narkar1,2, Blake A Johnson1,3, Rong Li1,4,5.   

Abstract

TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we confirmed that p53 is required for high mitotic fidelity. Our findings provide a revised view on how p53 safeguards against aneuploidy.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  P53; aneuploidy; organoids

Year:  2021        PMID： 34616871      PMCID： PMC8489959          DOI： 10.1080/23723556.2021.1938479

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.

Authors:  Lawrence A Donehower; Thierry Soussi; Anil Korkut; Yuexin Liu; Andre Schultz; Maria Cardenas; Xubin Li; Ozgun Babur; Teng-Kuei Hsu; Olivier Lichtarge; John N Weinstein; Rehan Akbani; David A Wheeler
Journal:  Cell Rep       Date:  2019-07-30       Impact factor: 9.423

2.  Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

Authors:  Alison M Taylor; Juliann Shih; Gavin Ha; Galen F Gao; Xiaoyang Zhang; Ashton C Berger; Steven E Schumacher; Chen Wang; Hai Hu; Jianfang Liu; Alexander J Lazar; Andrew D Cherniack; Rameen Beroukhim; Matthew Meyerson
Journal:  Cancer Cell       Date:  2018-04-02       Impact factor: 31.743

3.  Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing.

Authors:  Benedetta Artegiani; Delilah Hendriks; Joep Beumer; Rutger Kok; Xuan Zheng; Indi Joore; Susana Chuva de Sousa Lopes; Jeroen van Zon; Sander Tans; Hans Clevers
Journal:  Nat Cell Biol       Date:  2020-03-02       Impact factor: 28.824

Review 4.  Three-dimensional organotypic culture: experimental models of mammalian biology and disease.

Authors:  Eliah R Shamir; Andrew J Ewald
Journal:  Nat Rev Mol Cell Biol       Date:  2014-09-17       Impact factor: 94.444

5.  Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

Authors:  Sarah L Thompson; Duane A Compton
Journal:  J Cell Biol       Date:  2010-02-01       Impact factor: 10.539

Review 6.  Cellular Stress Associated with Aneuploidy.

Authors:  Jin Zhu; Hung-Ji Tsai; Molly R Gordon; Rong Li
Journal:  Dev Cell       Date:  2018-02-26       Impact factor: 12.270

7.  Hypo-osmotic-like stress underlies general cellular defects of aneuploidy.

Authors:  Hung-Ji Tsai; Anjali R Nelliat; Mohammad Ikbal Choudhury; Andrei Kucharavy; William D Bradford; Malcolm E Cook; Jisoo Kim; Devin B Mair; Sean X Sun; Michael C Schatz; Rong Li
Journal:  Nature       Date:  2019-05-08       Impact factor: 49.962

8.  p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway.

Authors:  Claudia Contadini; Laura Monteonofrio; Ilaria Virdia; Andrea Prodosmo; Davide Valente; Luciana Chessa; Antonio Musio; Luca L Fava; Cinzia Rinaldo; Giuliana Di Rocco; Silvia Soddu
Journal:  Cell Death Dis       Date:  2019-11-07       Impact factor: 8.469

9.  On the role of p53 in the cellular response to aneuploidy.

Authors:  Akshay Narkar; Blake A Johnson; Pandurang Bharne; Jin Zhu; Veena Padmanaban; Debojyoti Biswas; Andrew Fraser; Pablo A Iglesias; Andrew J Ewald; Rong Li
Journal:  Cell Rep       Date:  2021-03-23       Impact factor: 9.423

10.  Mitotic Kinases and p53 Signaling.

Authors:  Geun-Hyoung Ha; Eun-Kyoung Yim Breuer
Journal:  Biochem Res Int       Date:  2012-07-19
  10 in total

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