Literature DB >> 34616867

Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination.

Sébastien Coassolo1,2,3,4, Irwin Davidson1,2,3,4.   

Abstract

Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.
© 2021 Taylor & Francis Group, LLC.

Entities:  

Keywords:  NuRD complex; allosteric regulation; chromatin; melanoma; protein arginine deiminase

Year:  2021        PMID： 34616867      PMCID： PMC8489931          DOI： 10.1080/23723556.2021.1927446

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  The Rheumatoid Arthritis-Associated Citrullinome.

Authors:  Ronak Tilvawala; Son Hong Nguyen; Aaron J Maurais; Venkatesh V Nemmara; Mitesh Nagar; Ari J Salinger; Sunil Nagpal; Eranthie Weerapana; Paul R Thompson
Journal:  Cell Chem Biol       Date:  2018-04-05       Impact factor: 8.116

Review 2.  Understanding the Intersections between Metabolism and Cancer Biology.

Authors:  Matthew G Vander Heiden; Ralph J DeBerardinis
Journal:  Cell       Date:  2017-02-09       Impact factor: 41.582

3.  Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

Authors:  Charles Kung; Jeff Hixon; Sung Choe; Kevin Marks; Stefan Gross; Erin Murphy; Byron DeLaBarre; Giovanni Cianchetta; Shalini Sethumadhavan; Xiling Wang; Shunqi Yan; Yi Gao; Cheng Fang; Wentao Wei; Fan Jiang; Shaohui Wang; Kevin Qian; Jeff Saunders; Ed Driggers; Hin Koon Woo; Kaiko Kunii; Stuart Murray; Hua Yang; Katharine Yen; Wei Liu; Lewis C Cantley; Matthew G Vander Heiden; Shinsan M Su; Shengfang Jin; Francesco G Salituro; Lenny Dang
Journal:  Chem Biol       Date:  2012-09-21

Review 4.  PKM2, cancer metabolism, and the road ahead.

Authors:  Talya L Dayton; Tyler Jacks; Matthew G Vander Heiden
Journal:  EMBO Rep       Date:  2016-11-17       Impact factor: 8.807

5.  Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Authors:  Weibo Luo; Hongxia Hu; Ryan Chang; Jun Zhong; Matthew Knabel; Robert O'Meally; Robert N Cole; Akhilesh Pandey; Gregg L Semenza
Journal:  Cell       Date:  2011-05-27       Impact factor: 41.582

Review 6.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

Review 7.  Chemical biology of protein citrullination by the protein A arginine deiminases.

Authors:  Santanu Mondal; Paul R Thompson
Journal:  Curr Opin Chem Biol       Date:  2021-03-04       Impact factor: 8.972

8.  Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.

Authors:  Sébastien Coassolo; Guillaume Davidson; Luc Negroni; Giovanni Gambi; Sylvain Daujat; Christophe Romier; Irwin Davidson
Journal:  Nat Commun       Date:  2021-03-19       Impact factor: 14.919

9.  An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.

Authors:  Meng Yuan; Iain W McNae; Yiyuan Chen; Elizabeth A Blackburn; Martin A Wear; Paul A M Michels; Linda A Fothergill-Gilmore; Ted Hupp; Malcolm D Walkinshaw
Journal:  Biochem J       Date:  2018-05-31       Impact factor: 3.857

10.  The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression.

Authors:  Susanne Bornelöv; Nicola Reynolds; Maria Xenophontos; Sarah Gharbi; Ewan Johnstone; Robin Floyd; Meryem Ralser; Jason Signolet; Remco Loos; Sabine Dietmann; Paul Bertone; Brian Hendrich
Journal:  Mol Cell       Date:  2018-06-28       Impact factor: 17.970
  10 in total

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