O Oxlade1, S den Boon2, D Menzies3, D Falzon2, M Y Lane3, A Kanchar2, M Zignol2, A Matteelli4. 1. McGill International TB Centre, Montreal, QC, Canada. 2. Global TB Programme, World Health Organization, Geneva, Switzerland. 3. McGill International TB Centre, Montreal, QC, Canada, McGill University, Montreal, QC, Canada. 4. WHO Collaborating Centre for TB/HIV co-infection and for TB Elimination Strategy, University of Brescia, Brescia, Italy.
Abstract
BACKGROUND: In 2018, the WHO Member States committed to providing TB preventive treatment (TPT) to at least 30 million people by 2022. However, only 6.3 million people had initiated TPT by the end of 2019. Major knowledge gaps and research needs in diagnosis, treatment and the programmatic management of TPT (PMTPT) require to be addressed urgently. METHODS: In September 2019, a group of stakeholders involved in PMTPT in high TB burden countries met to develop an action agenda to support the global expansion of PMTPT. RESULTS: Barriers at the health system level, and priorities for research to overcome these, were identified for each step of the PMTPT cascade. The need for data on TPT financing, gaps and coverage under national health insurance schemes, as well as the need for mathematical and cost-effectiveness modelling of the impact of TPT on TB incidence and mortality were highlighted. Specific research needs were identified for high-risk populations such as household contacts of any age and people living with HIV, as well as other people at risk. CONCLUSIONS: The meeting facilitated agreement on a set of actions needed to ensure that PMTPT continues to expand to achieve the End TB Strategy targets.
BACKGROUND: In 2018, the WHO Member States committed to providing TB preventive treatment (TPT) to at least 30 million people by 2022. However, only 6.3 million people had initiated TPT by the end of 2019. Major knowledge gaps and research needs in diagnosis, treatment and the programmatic management of TPT (PMTPT) require to be addressed urgently. METHODS: In September 2019, a group of stakeholders involved in PMTPT in high TB burden countries met to develop an action agenda to support the global expansion of PMTPT. RESULTS: Barriers at the health system level, and priorities for research to overcome these, were identified for each step of the PMTPT cascade. The need for data on TPT financing, gaps and coverage under national health insurance schemes, as well as the need for mathematical and cost-effectiveness modelling of the impact of TPT on TB incidence and mortality were highlighted. Specific research needs were identified for high-risk populations such as household contacts of any age and people living with HIV, as well as other people at risk. CONCLUSIONS: The meeting facilitated agreement on a set of actions needed to ensure that PMTPT continues to expand to achieve the End TB Strategy targets.
Authors: Nicholas I Paton; Laurence Borand; Jubert Benedicto; Mar Mar Kyi; Asif Mujtaba Mahmud; Mohd Nor Norazmi; Nandini Sharma; Charoen Chuchottaworn; Yi-Wen Huang; Nastiti Kaswandani; Hoi Le Van; Grace C Y Lui; Tan Eang Mao Journal: Int J Infect Dis Date: 2019-07-10 Impact factor: 3.623
Authors: Miriam Harris; Amy Qi; Luke Jeagal; Nazi Torabi; Dick Menzies; Alexei Korobitsyn; Madhukar Pai; Ruvandhi R Nathavitharana; Faiz Ahmad Khan Journal: PLoS One Date: 2019-09-03 Impact factor: 3.240
Authors: Lucia Cilloni; Han Fu; Juan F Vesga; David Dowdy; Carel Pretorius; Sevim Ahmedov; Sreenivas A Nair; Andrei Mosneaga; Enos Masini; Suvanand Sahu; Nimalan Arinaminpathy Journal: EClinicalMedicine Date: 2020-10-24