Literature DB >> 3461462

Hexose transport control in a fibroblast metabolic mutant can be promoted more effectively by D-allose than by glucose.

D B Ullrey, H M Kalckar.   

Abstract

By studying the energy-requiring control of the hexose transport system (the transport "curb") in a lung fibroblast mutant called the phosphoglucose isomerase mutant (because it is devoid of the enzyme phosphoglucose isomerase) the following features were noted. The aldohexose D-allose, if added over 20 hr to a culture of the mutant, promotes the development of an intense curb of the hexose transport system, greatly surpassing that brought about by incubation with glucose. The allose-mediated curb can be circumvented by various metabolic inhibitors as well as by the presence of other aldohexoses such as mannose.

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Year:  1986        PMID： 3461462      PMCID： PMC386395          DOI： 10.1073/pnas.83.16.5858

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  Isolation of a Chinese hamster fibroblast mutant defective in hexose transport and aerobic glycolysis: its use to dissect the malignant phenotype.

Authors:  J Pouysségur; A Franchi; J C Salomon; P Silvestre
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

2.  A genetic approach to the role of energy metabolism in the growth of tumor cells: tumorigenicity of fibroblast mutants deficient either in glycolysis or in respiration.

Authors:  A Franchi; P Silvestre; J Pouysségur
Journal:  Int J Cancer       Date:  1981-06-15       Impact factor: 7.396

3.  Transport of D-allose by isolated fat-cells: an effect of adenosine triphosphate on insulin stimulated transport.

Authors:  E G Loten; D M Regen; C R Park
Journal:  J Cell Physiol       Date:  1976-12       Impact factor: 6.384

4.  Down-regulation of the hexose transport system: metabolic basis studied with a fibroblast mutant lacking phosphoglucose isomerase.

Authors:  D B Ullrey; A Franchi; J Pouyssegur; H M Kalckar
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

5.  Uncouplers of oxidative phosphorylation promote derepression of the hexose transport system in cultures of hamster cells.

Authors:  H M Kalckar; C W Christopher; D Ullrey
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

6.  Phosphorylation of glucose analog 3-O-methyl-D-glucose by rat heart.

Authors:  S J Gatley; J E Holden; J R Halama; T R DeGrado; D R Bernstein; C K Ng
Journal:  Biochem Biophys Res Commun       Date:  1984-03-30       Impact factor: 3.575

7.  Further clues concerning the vectors essential to regulation of hexose transport, as studied in fibroblast cultures from a metabolic mutant.

Authors:  H M Kalckar; D B Ullrey
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

8.  Derepression and carrier turnover: evidence for two distinct mechanisms of hexose transport regulation in animal cells.

Authors:  C W Christopher; W W Colby; D Ullrey
Journal:  J Cell Physiol       Date:  1976-12       Impact factor: 6.384

9.  Control of sugar transport in human fibroblasts independent of glucose metabolism or carrier-substrate interaction.

Authors:  R J Germinario; Z Chang; S Manuel; M Oliveira
Journal:  Biochem Biophys Res Commun       Date:  1985-05-16       Impact factor: 3.575
  9 in total
  3 in total

1.  MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.

Authors:  Carrie A Stoltzman; Mohan R Kaadige; Christopher W Peterson; Donald E Ayer
Journal:  J Biol Chem       Date:  2011-09-09       Impact factor: 5.157

2.  Tunicamycin tightens the glucose- and D-allose-mediated control of hexose transport in a metabolic fibroblast mutant.

Authors:  D B Ullrey; H M Kalckar
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

3.  Search for cellular phosphorylation products of D-allose.

Authors:  D B Ullrey; H M Kalckar
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205
  3 in total

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