| Literature DB >> 34611794 |
William A Hall1,2,3, Mandana Kamgar4,5,6, Beth A Erickson7,4,5, Sara Beltrán Ponce7, Susan Tsai4,5, Marja T Nevalainen8, Kathleen K Christians4,5, Ben George5,6, Kulwinder S Dua5,9, Abdul H Khan5,9, Douglas B Evans4,5, Asfar S Azmi10.
Abstract
Panc reatic ductal adenocarcinoma (PDAC) is a devastating malignancy. There have been few advances that have substantially improved overall survival in the past several years. On its current trajectory, the deaths from PDAC are expected to cross that from all gastrointestinal cancers combined by 2030. Radiation therapy is a technically very complex modality that bridges multiple different treatment strategies. It represents a hybrid among advanced diagnostic imaging, local (often ablative) intervention, and heterogeneous biological mechanisms contributing to normal and oncologic cell kill. In this article, we bring an overview of the several promising strategies that are currently being investigated to improve outcomes using radiation therapy for patients with PDAC.Entities:
Keywords: Advances in radiation for pancreatic cancer; Novel RT techniques; Pancreatic radiation therapy; Radiation sensitization
Mesh：
Year: 2021 PMID： 34611794 PMCID： PMC8767496 DOI： 10.1007/s10555-021-09993-z
Source DB: PubMed Journal: Cancer Metastasis Rev ISSN： 0167-7659 Impact factor: 9.237