[Structure/function/treatment in glaucoma: progress over the last 10 years].

Since the 1990s several so-called landmark studies were carried out, which played an important role in the management of glaucoma patients due to their multicenter, randomized and masked structure. The Ocular Hypertension Treatment Study (OHTS) and the Collaborative Initial Treatment Glaucoma Study (CIGTS) and their follow-up studies are especially important in the conservative glaucoma management and in the evaluation of structure and function. The OHTS examined if lowering of the intraocular pressure (IOP) treatment reduces the progression from ocular hypertension to primary open angle glaucoma and what risk factors influence the progression. The CIGTS examined the progression of glaucoma in patients treated either with pharmacotherapy or with surgery. The recent studies, the United Kingdom Glaucoma Treatment Study (UKGTS) and Glaucoma Automated Test Evaluation (GATE) investigated the influence of treatment with latanoprost on the development of visual field defects and examination of different screening tests in glaucoma, respectively. The OHTS provided results that justify prophylactic treatment as well as watchful waiting. The results of CIGTS showed that under certain conditions surgical treatment of a newly discovered glaucoma can be recommended for moderate to advanced glaucoma. In the UKGTS treatment with latanoprost reduced the intraocular pressure and also the progression of visual field defects in beginning and moderate glaucoma damage. The GATE study found no clear-cut advantage of screening examinations, with cost effectiveness and without a substantial proportion of diagnoses being missed.