| Literature DB >> 34608937 |
Yara-Natalie Abo1, Nigel Curtis1,2,3, Joshua Osowicki1,2,3, Gabrielle Haeusler1,2,4, Rachael Purcell1, Seilesh Kadambari1, Matthias De Wachter5, Koen Vanden Driessche6,7,8, Sven Dekeyzer9, Lee Coleman10, Nigel Crawford11, Steve Graham2,3, Ben Marais12,13, Amanda Gwee1,2,3.
Abstract
Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for prospective trials.Entities:
Keywords: central nervous system tuberculosis; infliximab; paradoxical reaction; tuberculous meningitis
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Year: 2021 PMID： 34608937 DOI： 10.1093/jpids/piab094
Source DB: PubMed Journal: J Pediatric Infect Dis Soc ISSN： 2048-7193 Impact factor: 3.164