| Literature DB >> 34608279 |
Renjian Xie1,2,3, Hang Yao1,2,4, Angelina S Mao5, Ye Zhu6, Dawei Qi1,2, Yongguang Jia1,2, Meng Gao1,2, Yunhua Chen1,2, Lin Wang1,2, Dong-An Wang7, Kun Wang8, Sa Liu9,10,11, Li Ren12,13,14, Chuanbin Mao15,16.
Abstract
The early stages of progressive degeneration of cartilage in articular joints are a hallmark of osteoarthritis. Healthy cartilage is lubricated by brush-like cartilage-binding nanofibres with a hyaluronan backbone and two key side chains (lubricin and lipid). Here, we show that hyaluronan backbones grafted with lubricin-like sulfonate-rich polymers or with lipid-like phosphocholine-rich polymers together enhance cartilage regeneration in a rat model of early osteoarthritis. These biomimetic brush-like nanofibres show a high affinity for cartilage proteins, form a lubrication layer on the cartilage surface and efficiently lubricate damaged human cartilage, lowering its friction coefficient to the low levels typical of native cartilage. Intra-articular injection of the two types of nanofibre into rats with surgically induced osteoarthritic joints led to cartilage regeneration and to the abrogation of osteoarthritis within 8 weeks. Biocompatible injectable lubricants that facilitate cartilage regeneration may offer a translational strategy for the treatment of early osteoarthritis.Entities:
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Year: 2021 PMID： 34608279 DOI： 10.1038/s41551-021-00785-y
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671