Literature DB >> 3460518

Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain.

S Omura, H Ikeda, F Malpartida, H M Kieser, D A Hopwood.   

Abstract

Hybrid antibiotics mederrhodins A and B were produced by a recombinant strain consisting of the medermycin-producing Streptomyces sp. strain AM7161 containing part of the gene clusters for actinorhodin biosynthesis of Streptomyces coelicolor A3(2). Mederrhodin A has a hydroxyl group at the C-6 position of the medermycin molecule, and mederrhodin B is dihydromederrhodin A. The antimicrobial activity of mederrhodin A resembled that of medermycin. Mederrhodin B was almost devoid of antimicrobial activity.

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Year:  1986        PMID： 3460518      PMCID： PMC180355          DOI： 10.1128/AAC.29.1.13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  New anthracycline antibiotics produced by interspecific recombinants of streptomycetes. I. Selection of Streptomyces violaceus subsp. iremyceticus, an iremycin-producing subspecies.

Authors:  B Schlegel; W F Fleck
Journal:  Z Allg Mikrobiol       Date:  1980

2.  Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.

Authors:  S Omura; N Sadakane; Y Tanaka; H Matsubara
Journal:  J Antibiot (Tokyo)       Date:  1983-07       Impact factor: 2.649

3.  Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms.

Authors:  N Sadakane; Y Tanaka; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1982-06       Impact factor: 2.649

4.  Hybrid biosynthesis and absolute configuration of macrolide antibiotic M-4365 G1.

Authors:  S Omura; H Ikeda; H Matsubara; N Sakakane
Journal:  J Antibiot (Tokyo)       Date:  1980-12       Impact factor: 2.649

5.  Interspecific recombination among aminoglycoside producing streptomycetes.

Authors:  N Mazieres; M Peyre; L Penasse
Journal:  J Antibiot (Tokyo)       Date:  1981-05       Impact factor: 2.649

6.  Cloning of antibiotic resistance and nutritional genes in streptomycetes.

Authors:  C J Thompson; J M Ward; D A Hopwood
Journal:  J Bacteriol       Date:  1982-08       Impact factor: 3.490

7.  Biosynthesis of nanaomycin. II. Purification and properties of nanaomycin D reductase involved in the formation of nanaomycin A from nanaomycin D1.

Authors:  S Omura; H Tanaka; S Minami; I Takahashi
Journal:  J Biochem       Date:  1981-08       Impact factor: 3.387

8.  Preparation of four new antibiotics from a mutant of Streptomyces fradiae.

Authors:  W T Shier; K L Rinehart; D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1969-05       Impact factor: 11.205

9.  Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867.

Authors:  Y Iwai; A Kora; Y Takahashi; T Hayashi; J Awaya; R Masuma; R Oiwa; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1978-10       Impact factor: 2.649

10.  The Streptomyces plasmid SCP2*: its functional analysis and development into useful cloning vectors.

Authors:  D J Lydiate; F Malpartida; D A Hopwood
Journal:  Gene       Date:  1985       Impact factor: 3.688
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  13 in total

1.  TESOTf-induced rearrangement of quinols. Efficient construction of the fully functionalized carbon skeleton of the griseusins by a divergent-reconvergent approach.

Authors:  Kathlyn A Parker; Thomas L Mindt; Yung-hyo Koh
Journal:  Org Lett       Date:  2006-04-27       Impact factor: 6.005

Review 2.  Thom Award Lecture. Trends in the search for bioactive microbial metabolites.

Authors:  S Omura
Journal:  J Ind Microbiol       Date:  1992-09

3.  Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.

Authors:  S G Kendrew; D A Hopwood; E N Marsh
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

4.  Tools for metabolic engineering in Streptomyces.

Authors:  Valerie Bekker; Amanda Dodd; Dean Brady; Karl Rumbold
Journal:  Bioengineered       Date:  2014 Sep-Oct       Impact factor: 3.269

Review 5.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

Review 6.  Streptomyces cloning: possible construction of novel compounds and regulation of antibiotic biosynthetic genes.

Authors:  P K Tomich
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

7.  Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis.

Authors:  M A Richardson; S Kuhstoss; M L Huber; L Ford; O Godfrey; J R Turner; R N Rao
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

8.  Biosynthesis of antibiotics in streptomycetes.

Authors:  N D Lomovskaya; G V Sezonov
Journal:  World J Microbiol Biotechnol       Date:  1992-12       Impact factor: 3.312

9.  Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions.

Authors:  P L Bartel; C B Zhu; J S Lampel; D C Dosch; N C Connors; W R Strohl; J M Beale; H G Floss
Journal:  J Bacteriol       Date:  1990-09       Impact factor: 3.490

10.  Cloning genes for the biosynthesis of a macrolide antibiotic.

Authors:  S E Fishman; K Cox; J L Larson; P A Reynolds; E T Seno; W K Yeh; R Van Frank; C L Hershberger
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205
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